Detailed information NTG0447282

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: GE021_RS07335
• Genome accession: NZ_CP053792
• Coordinates: 1471911..1474202 (+)
• Length: 763 a.a.
• NCBI ID: WP_003044330.1
• Uniprot ID: A0A2D4DPL6
• Organism: Streptococcus canis strain HL_77_1
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1470703..1471176	1471911..1474202	flank	735

Gene organization within MGE regions

Location: 1470703..1474202

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GE021_RS07325 (GE021_007320)	tnpA	1470703..1471176 (-)	474	WP_164406611.1	IS200/IS605 family transposase	-
GE021_RS07330 (GE021_007325)	-	1471380..1471610 (-)	231	WP_002983885.1	YkuJ family protein	-
GE021_RS07335 (GE021_007330)	clpE	1471911..1474202 (+)	2292	WP_003044330.1	ATP-dependent Clp protease ATP-binding subunit	Regulator

Sequence

Protein

• Length: 763 a.a.
• Molecular weight: 84830.02 Da
• Isoelectric Point: 5.4128

>NTDB_id=447282 GE021_RS07335 WP_003044330.1 1471911..1474202(+) (clpE) [Streptococcus canis strain HL_77_1]
MLCQNCNLNESTIHLYTNVNGKQRQVDLCQNCYQIMKTDPTNPILGGLNRGQKAQDRSSHPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRHGGNYNGQGQPQPQAPNQQAKGLLEEFGINVTDIARHGDIDPVIGRDEEITRVIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKIVDGTVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
IAKYKEMQAQKVNEQDIPIITEKNIEAIVEQKTNIPVGDLKEKEQSQLVNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSADNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTNSVLGELSNFFS
PEFMNRFDGIIEFKALSKDNLLHIVDLMLADVNQRLAYNNIDLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKDLRAVMTSNGNIMIKAAKKGETVPTTQEQGNNH

Nucleotide

• Length: 2292 bp

>NTDB_id=447282 GE021_RS07335 WP_003044330.1 1471911..1474202(+) (clpE) [Streptococcus canis strain HL_77_1]
ATGCTTTGTCAAAATTGTAATTTAAACGAATCAACCATTCATCTTTATACAAATGTTAATGGAAAACAAAGACAGGTTGA
CCTTTGTCAAAACTGTTACCAAATCATGAAAACAGACCCAACCAATCCTATTTTAGGCGGCCTAAACAGAGGACAAAAAG
CCCAAGATCGGTCTTCACATCCTTTCTTTGATGACTTTTTCGGCGACCTCAATAATTTTAGAGCCTTCGGTAATCTTCCT
AATACACCGCCTACACAAGCGGGCCAAAATGGCAACGGAGGAGGACGTCACGGTGGCAATTATAATGGGCAAGGGCAACC
ACAGCCGCAAGCCCCAAATCAGCAAGCAAAAGGCCTACTAGAAGAATTTGGCATTAACGTGACCGATATTGCAAGGCATG
GCGATATTGACCCTGTTATCGGCCGTGATGAGGAAATCACCCGTGTGATTGAAATCCTCAATCGCCGAACCAAAAATAAT
CCTGTGCTTATTGGTGAGCCAGGAGTTGGTAAAACTGCTGTTGTAGAAGGTTTGGCTCAAAAAATTGTTGATGGTACTGT
TCCTCATAAATTGCAGGGCAAACAAGTTATCCGTCTTGATGTGGTTAGTCTTGTTCAGGGAACAGGTATCCGTGGTCAAT
TTGAAGAGCGCATGCAGAAATTAATGGAAGAAATTCGCAATCGCAAGGATGTCATTCTCTTCATTGATGAAATTCATGAG
ATTGTCGGTGCCGGTTCTGCTGGCGATGGCAATATGGATGCTGGTAATATTTTAAAACCAGCCTTAGCCCGTGGTGAATT
GCAGCTCGTCGGTGCTACCACCTTAAATGAATACCGTATTATTGAAAAAGATGCCGCCTTAGAACGACGCATGCAGCCGG
TGAAAGTTGACGAACCTTCTGTAGAAGAAACCATTACGATTTTAAAAGGTATCCAACCCAAATACGAAGACTACCATCAT
GTCAAATATAGCCCAGCTGCTATTGAAGCTGCCGCTCATTTATCCAACCGCTATATTCAAGACCGTTTTCTTCCAGATAA
GGCTATTGACCTCTTGGACGAAGCTGGTTCCAAAATGAATTTAACCCTCAACTTTGTTGATCCGAAAGAGATTGACAAAC
GCCTTATTGAAGCAGAAAATCTCAAAGCCCAAGCTACTCGAGACGAAGACTATGAACGCGCCGCTTATTTCCGCGATCAA
ATTGCAAAATACAAAGAAATGCAGGCTCAAAAAGTCAATGAGCAAGATATTCCAATCATTACTGAAAAAAACATTGAAGC
TATTGTAGAGCAAAAAACTAATATTCCAGTTGGAGACTTGAAAGAAAAAGAACAGTCTCAACTTGTAAATTTAGCCAACG
ATCTAAAAGCACACGTGATTGGACAAGACGATGCTGTTGATAAAATTGCTAAGGCTATTCGTCGTAACCGCGTGGGACTT
GGTACGCCAAATCGTCCAATCGGTTCCTTCCTTTTTGTTGGACCGACTGGGGTCGGTAAAACGGAATTGTCTAAACAGCT
GGCTATTGAACTCTTTGGCTCGGCAGACAACATGATTCGCTTTGACATGTCCGAATACATGGAAAAACACGCTGTCGCCA
AATTAGTCGGAGCACCTCCAGGTTATGTCGGTTATGAAGAAGCCGGACAGTTAACCGAACAAGTTCGTCGCAATCCGTAT
TCCCTTATTCTCTTAGATGAGGTGGAGAAAGCCCATCCTGACGTCATGCACATGTTCTTGCAAGTTCTTGATGATGGCCG
TTTAACAGATGGTCAAGGACGAACAGTCAGCTTCAAGGACACCATTATTATCATGACTTCCAATGCTGGAACAGGCAAGA
GTGAAGCTTCTGTCGGATTTGGTGCGGCTAGAGAAGGACGGACAAATTCTGTTCTAGGTGAATTAAGCAACTTCTTCAGC
CCAGAATTCATGAACCGTTTTGATGGTATTATCGAATTTAAGGCCTTGAGCAAGGATAACCTCCTACACATCGTTGATTT
AATGTTAGCTGATGTTAATCAACGCTTAGCTTACAATAATATCGACCTAGATGTGACACAAAAGGTCAAAGAAAAATTAG
TTGACCTAGGCTATGATCCTAAAATGGGCGCTCGACCTCTTCGTCGCACTATTCAAGATTACATTGAAGATGCTATTACA
GACTACTATTTAGAACATCCAACTGAAAAAGACTTGCGTGCCGTTATGACAAGCAATGGGAACATTATGATTAAAGCCGC
TAAAAAAGGGGAAACCGTTCCTACTACCCAAGAACAGGGCAACAATCATTAA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (656-730)

• AAA domain (Cdc48 subfamily) (AAA_2) (485-648)

• AAA lid domain (AAA_lid_9) (300-397)

• ATPase family associated with various cellular activities (AAA) (AAA) (162-281)

3D structure

• AlphaFold DB: A0A2D4DPL6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	85.96	98.952	0.851
clpE	Streptococcus pneumoniae Rx1	84.058	99.476	0.836
clpE	Streptococcus pneumoniae D39	84.058	99.476	0.836
clpE	Streptococcus pneumoniae R6	84.058	99.476	0.836
clpE	Streptococcus pneumoniae TIGR4	83.926	99.476	0.835
clpC	Lactococcus lactis subsp. cremoris KW2	74.574	100	0.746
clpC	Bacillus subtilis subsp. subtilis str. 168	49.781	89.777	0.447
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46.584	84.404	0.393
clpC	Streptococcus pneumoniae Rx1	48	81.913	0.393
clpC	Streptococcus pneumoniae D39	48	81.913	0.393
clpC	Streptococcus pneumoniae TIGR4	47.84	81.913	0.392
clpC	Streptococcus mutans UA159	47.826	81.389	0.389
clpC	Streptococcus thermophilus LMD-9	46.795	81.782	0.383
clpC	Streptococcus thermophilus LMG 18311	46.474	81.782	0.38