Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HPELS_RS02375 Genome accession   NC_017063
Coordinates   486163..487947 (-) Length   594 a.a.
NCBI ID   WP_000774309.1    Uniprot ID   -
Organism   Helicobacter pylori ELS37     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 481163..492947
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HPELS_RS02345 (HPELS_02380) - 481503..481751 (+) 249 WP_000790557.1 RNA-binding protein -
  HPELS_RS02350 (HPELS_02385) - 481970..482791 (-) 822 WP_001263457.1 glycosyltransferase family 25 protein -
  HPELS_RS02355 (HPELS_02390) trxB 483192..484127 (-) 936 WP_000564428.1 thioredoxin-disulfide reductase -
  HPELS_RS02360 (HPELS_02395) trxA 484133..484453 (-) 321 WP_000020205.1 thioredoxin -
  HPELS_RS02365 (HPELS_02400) - 484542..484886 (-) 345 WP_001211674.1 YraN family protein -
  HPELS_RS02370 (HPELS_02405) - 484887..486152 (-) 1266 WP_000746782.1 homoserine dehydrogenase -
  HPELS_RS02375 (HPELS_02410) uvrC 486163..487947 (-) 1785 WP_000774309.1 excinuclease ABC subunit UvrC Machinery gene
  HPELS_RS02380 (HPELS_02415) - 487948..488409 (-) 462 WP_000437171.1 hypothetical protein -
  HPELS_RS02385 - 488401..488580 (+) 180 WP_000468799.1 hypothetical protein -
  HPELS_RS02390 (HPELS_02420) - 488592..489233 (-) 642 WP_000659329.1 ATP-binding cassette domain-containing protein -
  HPELS_RS02395 (HPELS_02425) - 489237..490897 (-) 1661 Protein_447 ABC transporter permease/substrate-binding protein -
  HPELS_RS02400 (HPELS_02430) - 490966..491412 (-) 447 WP_001081239.1 hypothetical protein -
  HPELS_RS02405 (HPELS_02435) motB 491409..492182 (-) 774 WP_001085358.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68649.89 Da        Isoelectric Point: 9.7130

>NTDB_id=44669 HPELS_RS02375 WP_000774309.1 486163..487947(-) (uvrC) [Helicobacter pylori ELS37]
MADLLSSLKNLPNSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGGNNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLS
ACSNEVLKELQEFISHQYSKKIALNIPKKGDKLALIEIAMKNAQEIFSQEKTSNKDLILEEARSLFNLECMPYRVEIFDT
SHHANSQCVGGMVVYENNAFQKNSYRHYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRVQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNIKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRN

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=44669 HPELS_RS02375 WP_000774309.1 486163..487947(-) (uvrC) [Helicobacter pylori ELS37]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTCCTAATAGCAGTGGCGTGTATCAATACTTTGATAAAAACCGCCAACT
GCTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCATAATAATGAAATCACGCCCA
ATCATCGTGCAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACGATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCTAAATACAACATTCTTTTAAGAGATGATAAAACTTA
CCCCTATATTTATATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTGGACAGCTTGTATGAGTTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGCTGTAAAGCCCCATGCGAGGATAAAATCACTAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCCCTCATTTATAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCCTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGATATTTTTGCTTTTTATGGTGGGAACAACAAGGCGGT
GTTAGTGAAAATGTTCATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTCAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATGCCTGAACAAATCTTATTGAGC
GCTTGTTCTAATGAAGTGCTTAAAGAATTGCAAGAATTTATCTCTCATCAATATTCTAAAAAAATCGCTCTTAATATCCC
TAAAAAGGGCGATAAACTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAGGAAAAAACCTCTA
ATAAAGATCTGATTTTAGAAGAAGCGCGATCGCTTTTTAATTTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGACACA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAACGCCTTCCAAAAAAATTCTTATCGGCA
CTACCATTTAAAAGGCTCTAACGAATACACTCAAATGAGCGAATTGCTTACCAGAAGGGCTTTAGACTTTGCTAAAGAGC
CACCGCCTAATTTATGGGTAATAGATGGAGGGAGGGTGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAGGCTTATCGTTCTAAAGGGGGCGCTAAAGACATTAT
CCATACGCCTAGCAACACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATAAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAACAAGAAAAAAA
CGCCGTTTTGAAAAAACGAAATTAA

Domains

Predicted by InterproScan.

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

96.965

99.832

0.968

Multiple sequence alignment