Detailed information NTG0446399

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: I5046_RS12435
• Genome accession: NZ_CP065355
• Coordinates: 2538312..2540420 (+)
• Length: 702 a.a.
• NCBI ID: WP_001063341.1
• Uniprot ID: -
• Organism: Staphylococcus aureus strain JW31330_O1_dhc
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 2533312..2545420

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I5046_RS12410 (I5046_12410)	-	2533376..2533594 (+)	219	WP_000011686.1	sterile alpha motif-like domain-containing protein	-
I5046_RS12415 (I5046_12415)	-	2533985..2534416 (+)	432	WP_196957502.1	CHAP domain-containing protein	-
I5046_RS12420 (I5046_12420)	-	2534556..2535836 (-)	1281	WP_001191003.1	hydroxymethylglutaryl-CoA reductase, degradative	-
I5046_RS12425 (I5046_12425)	-	2536091..2537257 (+)	1167	WP_000151978.1	hydroxymethylglutaryl-CoA synthase	-
I5046_RS12430 (I5046_12430)	-	2537428..2537949 (-)	522	WP_000262594.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
I5046_RS12435 (I5046_12435)	clpE	2538312..2540420 (+)	2109	WP_001063341.1	ATP-dependent Clp protease ATP-binding subunit ClpL	Regulator
I5046_RS12440 (I5046_12440)	-	2540487..2540657 (-)	171	WP_000111114.1	FeoB-associated Cys-rich membrane protein	-
I5046_RS12445 (I5046_12445)	feoB	2540670..2542664 (-)	1995	WP_000432894.1	ferrous iron transport protein B	-
I5046_RS12450 (I5046_12450)	-	2542676..2542903 (-)	228	WP_000932073.1	FeoA family protein	-

Sequence

Protein

• Length: 702 a.a.
• Molecular weight: 78080.61 Da
• Isoelectric Point: 4.7097

>NTDB_id=446399 I5046_RS12435 WP_001063341.1 2538312..2540420(+) (clpE) [Staphylococcus aureus strain JW31330_O1_dhc]
MNNNFFNSDFDSILRRMMQDMQNSNQTSNKKYYINSKEVSPEELAQFTQQGGNHSAEQSAQAFQQAALRQQGQQSGNGNY
LEQIGRNLTQEARDGLLDPVIGRDKEIQETAEVLSRRTKNNPILVGEAGVGKTAIVEGLAQAIVEGNVPAAIKDKEIISI
DISSLEAGTQYRGAFEENIQKLVEGVKSSQNAVLFFDEIHQIIGSGATGSDSGSKGLSDILKPALSRGEISIIGATTQDE
YRNNIMKDAALTRRFNEVLVNEPSAKDTVEILKGIREKFETHHQVKLPDDVLKACVDLSIQYIPQRLLPDKAIDVLDITA
AHLSAQSPAIDKVATEKRISELEHDKRKAVSAEEYKKADDIQNEIKSLQDKLENSNGEHTAVATVHDISDTIQRLTGIPV
SQMDANDIERLKNISSRLRSKIIGQDKAVEMVSRAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLAIDLFGNKDA
LIRLDMSEYSDTTAVSKMIGTTAGYVGYDDNSNTLTEKVRRNPYSVILFDEIEKANPQILTLLLQVMDDGNLTDGQGNVI
NFKNTIIICTSNAGFGNGTDQEYDDIMQEMKKFFRPEFLNRFNGIVEFLHLDKDALQDIVNLLLDDVQVTLNKKGITMNV
SQDAKDWLIEEGYDEELGARPLRRIVEQQVRDKITDYYLDHTDVKHVDLDIEDNELVVKGKS

Nucleotide

• Length: 2109 bp

>NTDB_id=446399 I5046_RS12435 WP_001063341.1 2538312..2540420(+) (clpE) [Staphylococcus aureus strain JW31330_O1_dhc]
ATGAATAACAATTTTTTCAATAGTGACTTTGATTCTATTTTACGAAGAATGATGCAAGACATGCAAAACTCAAATCAGAC
TAGTAACAAGAAATACTATATTAATAGTAAAGAAGTTTCACCGGAAGAATTAGCACAATTTACGCAACAAGGTGGTAATC
ATTCTGCCGAACAAAGTGCGCAAGCTTTTCAACAAGCAGCACTAAGACAACAAGGTCAACAAAGTGGCAATGGCAATTAT
TTAGAACAAATTGGTCGTAACTTAACGCAAGAGGCTCGTGATGGATTATTAGATCCAGTCATCGGTCGTGATAAAGAAAT
CCAAGAAACTGCAGAAGTCTTAAGTAGACGCACTAAAAACAATCCTATCCTAGTCGGAGAAGCTGGAGTTGGTAAAACTG
CGATTGTCGAAGGTTTAGCGCAAGCAATCGTTGAAGGGAACGTACCTGCAGCAATCAAAGATAAAGAAATTATATCTATA
GATATTTCATCGCTTGAAGCTGGAACGCAATATCGTGGCGCCTTTGAAGAAAACATCCAAAAGTTAGTTGAAGGCGTTAA
ATCATCACAAAATGCTGTGCTCTTCTTTGACGAAATTCACCAAATCATCGGTTCCGGCGCAACAGGTAGTGATTCCGGTA
GTAAAGGGTTATCTGATATTTTAAAACCAGCATTAAGTCGTGGTGAAATTTCAATTATAGGTGCAACGACTCAAGATGAA
TATCGCAATAATATCATGAAAGACGCTGCATTAACACGTCGTTTTAACGAGGTGCTGGTTAACGAACCAAGCGCAAAAGA
TACGGTTGAAATTTTAAAAGGAATTCGCGAAAAATTTGAAACACACCATCAAGTCAAATTACCTGATGACGTATTAAAGG
CATGTGTAGACTTATCCATTCAATATATTCCACAACGCTTATTACCTGACAAAGCAATCGATGTATTAGATATTACAGCT
GCACATTTATCTGCACAAAGCCCTGCTATTGATAAAGTCGCGACTGAAAAACGTATTTCTGAATTGGAACATGATAAGCG
TAAAGCTGTAAGTGCTGAAGAATATAAAAAAGCAGATGACATTCAAAATGAAATCAAATCTCTACAAGATAAATTAGAAA
ACAGTAATGGTGAACATACTGCAGTAGCAACTGTGCATGATATTTCTGATACCATTCAACGATTAACTGGTATTCCTGTA
TCTCAAATGGATGCCAATGACATTGAACGTTTAAAAAATATTTCTAGTCGTTTAAGAAGTAAAATCATCGGTCAAGATAA
AGCTGTAGAAATGGTTTCTCGTGCCATTCGTCGTAATCGAGCTGGTTTTGATGATGGCAATCGTCCAATTGGTAGCTTCC
TATTTGTCGGTCCTACTGGTGTTGGTAAAACAGAGCTTGCCAAACAGTTAGCCATTGATCTATTTGGTAATAAAGATGCA
CTTATTCGACTTGATATGAGTGAATATAGTGACACAACAGCTGTTTCAAAAATGATTGGTACAACTGCTGGTTATGTCGG
TTATGATGACAATTCAAATACATTAACTGAAAAAGTACGACGCAATCCATATTCAGTCATTCTATTTGATGAAATTGAAA
AGGCTAACCCACAAATATTAACATTATTACTACAAGTGATGGATGATGGTAATTTAACAGATGGTCAAGGTAACGTCATC
AACTTTAAAAACACAATCATTATTTGTACGTCAAACGCTGGTTTTGGTAACGGTACAGACCAAGAATACGATGACATTAT
GCAAGAAATGAAAAAATTCTTCCGCCCTGAATTTCTTAACCGCTTCAACGGCATCGTTGAATTCTTACATTTAGATAAAG
ATGCATTACAAGATATCGTCAACTTATTATTAGACGATGTACAAGTAACATTAAATAAAAAAGGTATTACGATGAATGTT
TCTCAAGATGCAAAAGATTGGTTAATTGAAGAGGGATATGATGAAGAGTTAGGCGCACGCCCATTAAGACGCATTGTTGA
ACAACAAGTGCGTGACAAAATAACAGATTATTATTTAGATCATACAGACGTTAAACATGTGGATTTAGATATCGAAGACA
ACGAATTAGTCGTCAAAGGTAAATCATGA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (448-603)

• ATPase family associated with various cellular activities (AAA) (AAA) (123-257)

• AAA lid domain (AAA_lid_9) (264-363)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (611-682)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	48.212	91.595	0.442
clpE	Streptococcus pneumoniae Rx1	47.812	87.892	0.42
clpE	Streptococcus pneumoniae D39	47.812	87.892	0.42
clpE	Streptococcus pneumoniae R6	47.812	87.892	0.42
clpE	Streptococcus pneumoniae TIGR4	47.812	87.892	0.42
clpC	Lactococcus lactis subsp. cremoris KW2	46.044	90.028	0.415
clpC	Bacillus subtilis subsp. subtilis str. 168	43.884	93.162	0.409
clpC	Streptococcus thermophilus LMD-9	44.96	89.031	0.4
clpC	Streptococcus thermophilus LMG 18311	44.8	89.031	0.399
clpC	Streptococcus pneumoniae TIGR4	43.77	89.174	0.39
clpC	Streptococcus pneumoniae Rx1	43.77	89.174	0.39
clpC	Streptococcus pneumoniae D39	43.77	89.174	0.39
clpC	Streptococcus mutans UA159	43.902	87.607	0.385
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.536	88.746	0.377