Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   HA037_RS09925 Genome accession   NZ_CP053636
Coordinates   2009367..2010716 (+) Length   449 a.a.
NCBI ID   WP_000815646.1    Uniprot ID   Q9XB96
Organism   Staphylococcus aureus strain 14640     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2009367..2040565 2009367..2010716 within 0


Gene organization within MGE regions


Location: 2009367..2040565
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HA037_RS09925 (HA037_09935) ccrA 2009367..2010716 (+) 1350 WP_000815646.1 cassette chromosome recombinase CcrA Machinery gene
  HA037_RS09930 (HA037_09940) ccrB 2010738..2012366 (+) 1629 WP_001186602.1 cassette chromosome recombinase CcrB Machinery gene
  HA037_RS09935 (HA037_09945) - 2012884..2013234 (+) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  HA037_RS09940 (HA037_09950) - 2013321..2013632 (+) 312 WP_000700853.1 DUF960 family protein -
  HA037_RS09945 (HA037_09955) - 2013650..2014156 (+) 507 WP_001092169.1 DUF1643 domain-containing protein -
  HA037_RS09950 (HA037_09960) - 2014177..2014494 (+) 318 WP_000659050.1 JAB domain-containing protein -
  HA037_RS09955 (HA037_09965) - 2014613..2015698 (+) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  HA037_RS09960 (HA037_09970) - 2015759..2017588 (+) 1830 WP_001666399.1 site-specific integrase -
  HA037_RS09965 (HA037_09975) - 2017595..2017972 (+) 378 WP_000361059.1 DUF6262 family protein -
  HA037_RS09970 (HA037_09980) - 2018123..2018905 (+) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  HA037_RS09975 (HA037_09985) erm(A) 2019031..2019762 (-) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  HA037_RS14460 (HA037_09990) - 2019845..2019904 (-) 60 WP_010959190.1 erythromycin resistance leader peptide -
  HA037_RS09985 (HA037_09995) - 2020296..2020958 (+) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  HA037_RS09995 (HA037_10005) - 2021303..2021941 (-) 639 Protein_1951 sulfite exporter TauE/SafE family protein -
  HA037_RS10000 (HA037_10010) cstR 2021941..2022201 (-) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  HA037_RS10005 (HA037_10015) - 2022337..2023401 (+) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  HA037_RS10010 (HA037_10020) cstB 2023434..2024768 (+) 1335 Protein_1954 persulfide dioxygenase-sulfurtransferase CstB -
  HA037_RS10015 (HA037_10025) - 2024882..2025991 (-) 1110 WP_000943131.1 ROK family transcriptional regulator -
  HA037_RS10020 (HA037_10030) psm-mec 2026346..2026414 (+) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  HA037_RS10025 (HA037_10035) mecI 2026499..2026870 (-) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  HA037_RS10030 (HA037_10040) mecR1 2026870..2028627 (-) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  HA037_RS10035 (HA037_10045) mecA 2028724..2030733 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  HA037_RS10040 (HA037_10050) - 2030779..2031207 (-) 429 WP_000872606.1 MaoC family dehydratase -
  HA037_RS10045 (HA037_10055) - 2031304..2032047 (-) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  HA037_RS10050 (HA037_10060) - 2032312..2032986 (+) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  HA037_RS10055 (HA037_10065) - 2033157..2035082 (-) 1926 WP_002485723.1 heavy metal translocating P-type ATPase -
  HA037_RS10060 (HA037_10070) - 2035412..2035738 (-) 327 WP_000391495.1 metalloregulator ArsR/SmtB family transcription factor -
  HA037_RS10065 (HA037_10075) - 2035945..2036304 (+) 360 WP_001631039.1 hypothetical protein -
  HA037_RS10070 (HA037_10080) - 2036416..2036754 (-) 339 Protein_1966 recombinase family protein -
  HA037_RS10075 (HA037_10085) - 2036763..2037392 (+) 630 Protein_1967 hypothetical protein -
  HA037_RS10080 (HA037_10090) ccrA 2037579..2038940 (+) 1362 WP_001631036.1 cassette chromosome recombinase CcrA Machinery gene
  HA037_RS10085 (HA037_10095) ccrB 2038937..2040565 (+) 1629 WP_001631035.1 cassette chromosome recombinase CcrB Machinery gene

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52607.20 Da        Isoelectric Point: 9.9585

>NTDB_id=445840 HA037_RS09925 WP_000815646.1 2009367..2010716(+) (ccrA) [Staphylococcus aureus strain 14640]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=445840 HA037_RS09925 WP_000815646.1 2009367..2010716(+) (ccrA) [Staphylococcus aureus strain 14640]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9XB96

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

100

100

1
  ccrA Staphylococcus aureus COL

74.833

100

0.748