Detailed information NTG0445808

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HA037_RS00460
• Genome accession: NZ_CP053636
• Coordinates: 81605..82648 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 14640
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76605..87648

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HA037_RS00430 (HA037_00430)	-	77031..77141 (+)	111	WP_001790257.1	hypothetical protein	-
HA037_RS00435 (HA037_00435)	-	77170..77583 (+)	414	WP_001557448.1	hypothetical protein	-
HA037_RS00440 (HA037_00440)	-	78014..79000 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
HA037_RS00445 (HA037_00445)	map	79531..80289 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HA037_RS00450 (HA037_00450)	-	80506..80892 (+)	387	WP_001110179.1	hypothetical protein	-
HA037_RS00455 (HA037_00455)	liaF	80907..81608 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HA037_RS00460 (HA037_00460)	vraS	81605..82648 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HA037_RS00465 (HA037_00465)	vraR	82638..83267 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
HA037_RS00470 (HA037_00470)	-	83380..84597 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
HA037_RS00475 (HA037_00475)	-	84875..85150 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
HA037_RS00480 (HA037_00480)	-	85157..85621 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HA037_RS00485 (HA037_00485)	-	85768..85968 (+)	201	WP_000180460.1	DUF1128 family protein	-
HA037_RS00490 (HA037_00490)	-	85971..87227 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=445808 HA037_RS00460 WP_001017131.1 81605..82648(+) (vraS) [Staphylococcus aureus strain 14640]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=445808 HA037_RS00460 WP_001017131.1 81605..82648(+) (vraS) [Staphylococcus aureus strain 14640]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1