Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   HA034_RS11465 Genome accession   NZ_CP053356
Coordinates   2260229..2261590 (+) Length   453 a.a.
NCBI ID   WP_001631036.1    Uniprot ID   -
Organism   Staphylococcus aureus strain 14507     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2229086..2263215 2260229..2261590 within 0


Gene organization within MGE regions


Location: 2229086..2263215
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HA034_RS11300 (HA034_11305) ccrA 2229086..2230435 (+) 1350 WP_000815646.1 cassette chromosome recombinase CcrA Machinery gene
  HA034_RS11305 (HA034_11310) - 2230457..2232084 (+) 1628 Protein_2183 recombinase family protein -
  HA034_RS11310 (HA034_11315) - 2232602..2232952 (+) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  HA034_RS11315 (HA034_11320) - 2233039..2233350 (+) 312 WP_000700853.1 DUF960 family protein -
  HA034_RS11320 (HA034_11325) - 2233368..2233874 (+) 507 WP_001092169.1 DUF1643 domain-containing protein -
  HA034_RS11325 (HA034_11330) - 2233895..2234212 (+) 318 WP_000659050.1 JAB domain-containing protein -
  HA034_RS11330 (HA034_11335) - 2234331..2235417 (+) 1087 Protein_2188 tyrosine-type recombinase/integrase -
  HA034_RS11335 (HA034_11340) - 2235414..2237308 (+) 1895 Protein_2189 site-specific integrase -
  HA034_RS11340 (HA034_11345) - 2237315..2237693 (+) 379 Protein_2190 DUF6262 family protein -
  HA034_RS11345 (HA034_11350) - 2237844..2238626 (+) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  HA034_RS11350 (HA034_11355) erm(A) 2238752..2239484 (-) 733 Protein_2192 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  HA034_RS14820 (HA034_11360) - 2239494..2239553 (-) 60 WP_010959190.1 erythromycin resistance leader peptide -
  HA034_RS11360 (HA034_11365) - 2239947..2240611 (+) 665 Protein_2194 class I SAM-dependent methyltransferase -
  HA034_RS11370 (HA034_11375) - 2240956..2241594 (-) 639 Protein_2195 sulfite exporter TauE/SafE family protein -
  HA034_RS11375 (HA034_11380) cstR 2241594..2241854 (-) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  HA034_RS11380 (HA034_11385) - 2241990..2243054 (+) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  HA034_RS11385 (HA034_11390) cstB 2243087..2244421 (+) 1335 Protein_2198 persulfide dioxygenase-sulfurtransferase CstB -
  HA034_RS11390 (HA034_11395) - 2244535..2245665 (-) 1131 WP_010922808.1 ROK family transcriptional regulator -
  HA034_RS11395 (HA034_11400) psm-mec 2245999..2246067 (+) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  HA034_RS11400 (HA034_11405) mecI 2246152..2246523 (-) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  HA034_RS11405 (HA034_11410) mecR1 2246523..2248280 (-) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  HA034_RS11410 (HA034_11415) mecA 2248377..2250386 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  HA034_RS11415 (HA034_11420) - 2250432..2250860 (-) 429 WP_000872606.1 MaoC family dehydratase -
  HA034_RS11420 (HA034_11425) - 2250957..2251700 (-) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  HA034_RS11425 (HA034_11430) - 2251965..2252639 (+) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  HA034_RS11430 (HA034_11435) - 2252671..2252910 (-) 240 WP_001282728.1 hypothetical protein -
  HA034_RS11435 (HA034_11440) - 2253325..2254581 (-) 1257 WP_000566670.1 DUF3578 domain-containing protein -
  HA034_RS11440 (HA034_11445) - 2255807..2257732 (-) 1926 WP_002485723.1 heavy metal translocating P-type ATPase -
  HA034_RS11445 (HA034_11450) - 2258062..2258388 (-) 327 WP_000391495.1 metalloregulator ArsR/SmtB family transcription factor -
  HA034_RS11450 (HA034_11455) - 2258595..2258954 (+) 360 WP_001631039.1 hypothetical protein -
  HA034_RS11455 (HA034_11460) - 2259066..2259404 (-) 339 Protein_2212 recombinase family protein -
  HA034_RS11460 (HA034_11465) - 2259413..2260042 (+) 630 Protein_2213 hypothetical protein -
  HA034_RS11465 (HA034_11470) ccrA 2260229..2261590 (+) 1362 WP_001631036.1 cassette chromosome recombinase CcrA Machinery gene
  HA034_RS11470 (HA034_11475) ccrB 2261587..2263215 (+) 1629 WP_001631035.1 cassette chromosome recombinase CcrB Machinery gene

Sequence

Protein


Download         Length: 453 a.a.        Molecular weight: 53316.45 Da        Isoelectric Point: 9.8596

>NTDB_id=444305 HA034_RS11465 WP_001631036.1 2260229..2261590(+) (ccrA) [Staphylococcus aureus strain 14507]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI

Nucleotide


Download         Length: 1362 bp        

>NTDB_id=444305 HA034_RS11465 WP_001631036.1 2260229..2261590(+) (ccrA) [Staphylococcus aureus strain 14507]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(168-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

54.628

97.792

0.534
  ccrA Staphylococcus aureus N315

50.564

97.792

0.494