Detailed information NTG0444263

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HA035_RS13245
• Genome accession: NZ_CP053353
• Coordinates: 2670702..2671745 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 16405
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2665702..2676745

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HA035_RS13215 (HA035_13220)	-	2666120..2667376 (-)	1257	WP_001795438.1	aminopeptidase	-
HA035_RS13220 (HA035_13225)	-	2667379..2667579 (-)	201	WP_000180461.1	DUF1128 family protein	-
HA035_RS13225 (HA035_13230)	-	2667726..2668190 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HA035_RS13230 (HA035_13235)	-	2668197..2668472 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
HA035_RS13235 (HA035_13240)	-	2668750..2669967 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
HA035_RS13240 (HA035_13245)	vraR	2670083..2670712 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
HA035_RS13245 (HA035_13250)	vraS	2670702..2671745 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HA035_RS13250 (HA035_13255)	liaF	2671742..2672443 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HA035_RS13255 (HA035_13260)	-	2672458..2672844 (-)	387	WP_173950187.1	hypothetical protein	-
HA035_RS13260 (HA035_13265)	map	2673061..2673819 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HA035_RS13265 (HA035_13270)	-	2674406..2675392 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
HA035_RS13270 (HA035_13275)	-	2675823..2676236 (-)	414	WP_001549145.1	hypothetical protein	-
HA035_RS13275 (HA035_13280)	-	2676265..2676375 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=444263 HA035_RS13245 WP_001017131.1 2670702..2671745(-) (vraS) [Staphylococcus aureus strain 16405]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=444263 HA035_RS13245 WP_001017131.1 2670702..2671745(-) (vraS) [Staphylococcus aureus strain 16405]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1