Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   MGAS15252_RS05225 Genome accession   NC_017040
Coordinates   1068956..1070761 (-) Length   601 a.a.
NCBI ID   WP_011054652.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS15252     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1048576..1095758 1068956..1070761 within 0


Gene organization within MGE regions


Location: 1048576..1095758
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS15252_RS05135 (MGAS15252_1057) - 1048614..1049888 (-) 1275 WP_014407660.1 polysaccharide deacetylase family protein -
  MGAS15252_RS05140 (MGAS15252_1058) - 1049983..1051410 (-) 1428 WP_014407661.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  MGAS15252_RS05145 (MGAS15252_1059) ptsP 1051595..1053328 (-) 1734 WP_002984033.1 phosphoenolpyruvate--protein phosphotransferase -
  MGAS15252_RS05150 (MGAS15252_1060) - 1053333..1053596 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  MGAS15252_RS05155 (MGAS15252_1061) - 1053989..1054207 (+) 219 WP_002989242.1 redoxin NrdH -
  MGAS15252_RS05160 (MGAS15252_1062) nrdE 1054227..1056386 (+) 2160 WP_014407663.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  MGAS15252_RS05165 (MGAS15252_1064) nrdF 1056848..1057807 (+) 960 WP_011017933.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  MGAS15252_RS05170 (MGAS15252_1065) - 1057869..1059095 (+) 1227 WP_021775375.1 chloride channel protein -
  MGAS15252_RS09025 (MGAS15252_1066) - 1059191..1060342 (+) 1152 Protein_987 IS3 family transposase -
  MGAS15252_RS05190 (MGAS15252_1067) - 1060440..1061135 (-) 696 WP_002984013.1 CPBP family intramembrane glutamic endopeptidase -
  MGAS15252_RS05195 (MGAS15252_1068) - 1061154..1061915 (-) 762 WP_014407666.1 DUF3169 family protein -
  MGAS15252_RS05200 (MGAS15252_1069) - 1061912..1062127 (-) 216 WP_011054648.1 helix-turn-helix transcriptional regulator -
  MGAS15252_RS05205 (MGAS15252_1071) alaS 1062488..1065106 (-) 2619 WP_014407667.1 alanine--tRNA ligase -
  MGAS15252_RS05210 (MGAS15252_1072) prsA 1065493..1066548 (-) 1056 WP_014407668.1 peptidylprolyl isomerase PrsA -
  MGAS15252_RS05215 (MGAS15252_1073) - 1066611..1067318 (-) 708 WP_002989211.1 O-methyltransferase -
  MGAS15252_RS05220 (MGAS15252_1074) - 1067384..1068580 (-) 1197 WP_011054651.1 L-lactate MFS transporter -
  MGAS15252_RS05225 (MGAS15252_1075) pepF 1068956..1070761 (-) 1806 WP_011054652.1 oligoendopeptidase F Regulator
  MGAS15252_RS05230 (MGAS15252_1076) - 1070774..1071736 (-) 963 WP_014407670.1 competence protein CoiA -
  MGAS15252_RS05235 (MGAS15252_1077) - 1072033..1072749 (-) 717 Protein_997 pseudouridine synthase -
  MGAS15252_RS05240 (MGAS15252_1078) nagB 1072868..1073572 (-) 705 WP_002995779.1 glucosamine-6-phosphate deaminase -
  MGAS15252_RS05245 (MGAS15252_1079) queA 1073774..1074802 (+) 1029 WP_002995782.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  MGAS15252_RS05250 (MGAS15252_1080) - 1074809..1076029 (+) 1221 WP_002983986.1 DUF3114 domain-containing protein -
  MGAS15252_RS05255 (MGAS15252_1081) - 1076143..1076733 (-) 591 WP_002983984.1 serine hydrolase -
  MGAS15252_RS05260 (MGAS15252_1082) - 1076730..1076978 (-) 249 WP_011054656.1 hypothetical protein -
  MGAS15252_RS05265 (MGAS15252_1083) - 1076963..1077190 (-) 228 WP_011054657.1 hypothetical protein -
  MGAS15252_RS05270 (MGAS15252_1084) sodA 1077357..1077962 (-) 606 WP_011054658.1 superoxide dismutase SodA -
  MGAS15252_RS05275 (MGAS15252_1085) holA 1078059..1079099 (-) 1041 WP_011888795.1 DNA polymerase III subunit delta -
  MGAS15252_RS05280 (MGAS15252_1086) - 1079170..1081413 (-) 2244 WP_014407671.1 DNA internalization-related competence protein ComEC/Rec2 -
  MGAS15252_RS05285 (MGAS15252_1087) - 1081394..1082056 (-) 663 WP_002983967.1 ComEA family DNA-binding protein -
  MGAS15252_RS05290 (MGAS15252_1088) - 1082256..1082996 (-) 741 WP_041174344.1 lysophospholipid acyltransferase family protein -
  MGAS15252_RS05295 (MGAS15252_1089) - 1083114..1083890 (+) 777 WP_010922438.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  MGAS15252_RS05300 (MGAS15252_1090) - 1083880..1084158 (+) 279 WP_002989164.1 GIY-YIG nuclease family protein -
  MGAS15252_RS05305 (MGAS15252_1091) - 1084182..1086182 (-) 2001 WP_014407674.1 potassium transporter Kup -
  MGAS15252_RS05310 (MGAS15252_1092) - 1086310..1087929 (-) 1620 WP_014407675.1 DEAD/DEAH box helicase -
  MGAS15252_RS05315 (MGAS15252_1093) - 1088236..1089780 (-) 1545 WP_014407676.1 peptide chain release factor 3 -
  MGAS15252_RS05320 (MGAS15252_1095) - 1090028..1090723 (-) 696 WP_014407678.1 TIGR02206 family membrane protein -
  MGAS15252_RS05325 (MGAS15252_1096) - 1090803..1092194 (-) 1392 WP_010922441.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  MGAS15252_RS05330 (MGAS15252_1097) - 1092385..1093431 (-) 1047 WP_002989146.1 D-alanine--D-alanine ligase -
  MGAS15252_RS05335 (MGAS15252_1098) recR 1093532..1094128 (-) 597 WP_002983939.1 recombination mediator RecR -
  MGAS15252_RS09285 (MGAS15252_1099) - 1094175..1094366 (-) 192 WP_014407679.1 hypothetical protein -
  MGAS15252_RS05345 (MGAS15252_1100) - 1094927..1095706 (-) 780 WP_014407680.1 formate/nitrite transporter family protein -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69341.19 Da        Isoelectric Point: 4.7093

>NTDB_id=44404 MGAS15252_RS05225 WP_011054652.1 1068956..1070761(-) (pepF) [Streptococcus pyogenes MGAS15252]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=44404 MGAS15252_RS05225 WP_011054652.1 1068956..1070761(-) (pepF) [Streptococcus pyogenes MGAS15252]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAATT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATCATGACAGAAGC
TCTCTTAAATGAGGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Peptidase family M3 (Peptidase_M3)

(202-581)

Oligopeptidase F (Peptidase_M3_N)

(112-181)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

71.215

100

0.712

Multiple sequence alignment