Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   C528_RS03505 Genome accession   NZ_CP053256
Coordinates   745419..747203 (-) Length   594 a.a.
NCBI ID   WP_001916405.1    Uniprot ID   -
Organism   Helicobacter pylori A45     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 740419..752203
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C528_RS03475 (C528_003455) - 740821..741069 (+) 249 WP_000790557.1 RNA-binding protein -
  C528_RS03480 (C528_003460) - 741268..742089 (-) 822 WP_001916402.1 glycosyltransferase family 25 protein -
  C528_RS03485 (C528_003465) trxB 742449..743384 (-) 936 WP_000564423.1 thioredoxin-disulfide reductase -
  C528_RS03490 (C528_003470) trxA 743390..743710 (-) 321 WP_000020204.1 thioredoxin -
  C528_RS03495 (C528_003475) - 743798..744142 (-) 345 WP_001916403.1 YraN family protein -
  C528_RS03500 (C528_003480) - 744143..745408 (-) 1266 WP_001916404.1 homoserine dehydrogenase -
  C528_RS03505 (C528_003485) uvrC 745419..747203 (-) 1785 WP_001916405.1 excinuclease ABC subunit UvrC Machinery gene
  C528_RS03510 (C528_003490) - 747204..747665 (-) 462 WP_001916406.1 hypothetical protein -
  C528_RS03515 (C528_003495) - 747657..747836 (+) 180 WP_000468793.1 hypothetical protein -
  C528_RS03520 (C528_003500) - 747848..748489 (-) 642 WP_001916407.1 ATP-binding cassette domain-containing protein -
  C528_RS03525 (C528_003505) - 748493..750154 (-) 1662 WP_001916408.1 ABC transporter permease/substrate-binding protein -
  C528_RS03530 (C528_003510) - 750223..750660 (-) 438 WP_001031792.1 hypothetical protein -
  C528_RS03535 (C528_003515) motB 750664..751431 (-) 768 WP_001916409.1 flagellar motor protein MotB -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68775.11 Da        Isoelectric Point: 9.7097

>NTDB_id=443775 C528_RS03505 WP_001916405.1 745419..747203(-) (uvrC) [Helicobacter pylori A45]
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIRNDEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYLKIAKECLEMIENKDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYSGNNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLIPEQILLN
ACSNEMLKELQEFISHQYSKKIALNIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDV
SHHANSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYTQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTANDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=443775 C528_RS03505 WP_001916405.1 745419..747203(-) (uvrC) [Helicobacter pylori A45]
ATGGCTGATTTATTGTCTAGTTTGAAAAACCTTTCTCATAGTAGTGGCGTGTATCAATATTTTGACAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAACGCATCAAAAGCTATTTTTCCATCCGTAATGATGAAATCACGCCCA
ATCATCGCGCAAGCTTACGCATCCAAATGATGGTCAAACAGATCGCTTTTTTAGAAACGATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACCGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGTCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTAGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTTGAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAAACTCATCAAAGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCCTTTACTTGTATGGATTTAGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATAGTGGGAACAATAAGGCGGT
GTTGGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTGCCTTTGATTCCTGAACAGATCTTGTTGAAC
GCTTGCTCTAATGAAATGCTTAAAGAATTGCAAGAATTTATCTCCCATCAATATTCTAAAAAAATCGCTCTTAATATTCC
TAAAAAAGGCGACAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTCAAATTAGAGTGCATGCCTTATAGGGTGGAAATCTTTGATGTA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAACGCATTCCAAAAAAACTCTTATCGGCG
CTACCATTTAAAAGGCTCTAATGAATACACTCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCCAAAGAAC
CACCGCCTAATTTGTGGGTGATCGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATTAT
CCACACCGCTAACGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCATAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGTATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAATCTAA

Domains

Predicted by InterproScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrB/uvrC motif (UVR)

(205-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.138

100

0.971