Detailed information NTG0044374

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: MGAS15252_RS00260
• Genome accession: NC_017040
• Coordinates: 47102..48013 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes MGAS15252
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 42102..53013

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS15252_RS00240 (MGAS15252_0051)	purE	42688..43179 (+)	492	WP_041174354.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
MGAS15252_RS00245 (MGAS15252_0052)	purK	43166..44239 (+)	1074	WP_014407196.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
MGAS15252_RS00250 (MGAS15252_0053)	-	44241..45659 (+)	1419	WP_011888524.1	hypothetical protein	-
MGAS15252_RS00255 (MGAS15252_0054)	purB	45679..46971 (+)	1293	WP_014407197.1	adenylosuccinate lyase	-
MGAS15252_RS00260 (MGAS15252_0055)	comR	47102..48013 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
MGAS15252_RS09320	comS	48097..48192 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
MGAS15252_RS00265 (MGAS15252_0056)	ruvB	48239..49237 (+)	999	WP_014407198.1	Holliday junction branch migration DNA helicase RuvB	-
MGAS15252_RS00270 (MGAS15252_0057)	-	49375..49812 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
MGAS15252_RS00275 (MGAS15252_0058)	-	49835..50236 (+)	402	WP_012560369.1	MORN repeat-containing protein	-
MGAS15252_RS00280 (MGAS15252_0059)	-	50233..52008 (+)	1776	WP_014407199.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=44374 MGAS15252_RS00260 WP_002986681.1 47102..48013(+) (comR) [Streptococcus pyogenes MGAS15252]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=44374 MGAS15252_RS00260 WP_002986681.1 47102..48013(+) (comR) [Streptococcus pyogenes MGAS15252]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATTATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462