Detailed information NTG0443345

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HLG72_RS09980
• Genome accession: NZ_CP053185
• Coordinates: 2009956..2010999 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain Guangzhou-SAU749
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2004956..2015999

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HLG72_RS09950 (HLG72_09955)	-	2005377..2006633 (-)	1257	WP_078065149.1	aminopeptidase	-
HLG72_RS09955 (HLG72_09960)	-	2006636..2006836 (-)	201	WP_000180460.1	DUF1128 family protein	-
HLG72_RS09960 (HLG72_09965)	-	2006983..2007447 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HLG72_RS09965 (HLG72_09970)	-	2007454..2007729 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
HLG72_RS09970 (HLG72_09975)	-	2008007..2009224 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
HLG72_RS09975 (HLG72_09980)	vraR	2009337..2009966 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
HLG72_RS09980 (HLG72_09985)	vraS	2009956..2010999 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HLG72_RS09985 (HLG72_09990)	liaF	2010996..2011697 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HLG72_RS09990 (HLG72_09995)	-	2011712..2012098 (-)	387	WP_001110179.1	hypothetical protein	-
HLG72_RS09995 (HLG72_10000)	map	2012315..2013073 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HLG72_RS10000 (HLG72_10005)	-	2013602..2014588 (+)	987	WP_000999708.1	aromatic acid exporter family protein	-
HLG72_RS10005 (HLG72_10010)	-	2015021..2015434 (-)	414	WP_025174552.1	hypothetical protein	-
HLG72_RS10010 (HLG72_10015)	-	2015463..2015573 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=443345 HLG72_RS09980 WP_001017131.1 2009956..2010999(-) (vraS) [Staphylococcus aureus strain Guangzhou-SAU749]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=443345 HLG72_RS09980 WP_001017131.1 2009956..2010999(-) (vraS) [Staphylococcus aureus strain Guangzhou-SAU749]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1