Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   HLB22_RS09640 Genome accession   NZ_CP053101
Coordinates   1973543..1974172 (-) Length   209 a.a.
NCBI ID   WP_000153535.1    Uniprot ID   W8TS97
Organism   Staphylococcus aureus strain EDCC5398     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1968543..1979172
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HLB22_RS09610 (HLB22_09610) - 1968963..1969493 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  HLB22_RS09615 (HLB22_09615) - 1969583..1970839 (-) 1257 WP_075583716.1 aminopeptidase -
  HLB22_RS09620 (HLB22_09620) - 1970842..1971042 (-) 201 WP_000180460.1 DUF1128 family protein -
  HLB22_RS09625 (HLB22_09625) - 1971189..1971653 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  HLB22_RS09630 (HLB22_09630) - 1971660..1971935 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  HLB22_RS09635 (HLB22_09635) - 1972213..1973430 (+) 1218 WP_000037075.1 YihY/virulence factor BrkB family protein -
  HLB22_RS09640 (HLB22_09640) vraR 1973543..1974172 (-) 630 WP_000153535.1 two-component system response regulator VraR Regulator
  HLB22_RS09645 (HLB22_09645) vraS 1974162..1975205 (-) 1044 WP_029271699.1 sensor histidine kinase Regulator
  HLB22_RS09650 (HLB22_09650) liaF 1975202..1975903 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  HLB22_RS09655 (HLB22_09655) - 1975918..1976304 (-) 387 WP_001110179.1 hypothetical protein -
  HLB22_RS09660 (HLB22_09660) map 1976521..1977279 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  HLB22_RS09665 (HLB22_09665) - 1977808..1978794 (+) 987 WP_000999713.1 aromatic acid exporter family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23559.32 Da        Isoelectric Point: 5.3935

>NTDB_id=443048 HLB22_RS09640 WP_000153535.1 1973543..1974172(-) (vraR) [Staphylococcus aureus strain EDCC5398]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=443048 HLB22_RS09640 WP_000153535.1 1973543..1974172(-) (vraR) [Staphylococcus aureus strain EDCC5398]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB W8TS97

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

100

100

1
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373