Detailed information NTG0044058

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: M013TW_RS09880
• Genome accession: NC_016928
• Coordinates: 1981729..1982772 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus subsp. aureus M013
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1976729..1987772

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M013TW_RS09850 (M013TW_1915)	-	1977150..1978406 (-)	1257	WP_078065149.1	aminopeptidase	-
M013TW_RS09855 (M013TW_1916)	-	1978409..1978609 (-)	201	WP_000180460.1	DUF1128 family protein	-
M013TW_RS09860 (M013TW_1917)	-	1978756..1979220 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
M013TW_RS09865 (M013TW_1918)	-	1979227..1979502 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
M013TW_RS09870 (M013TW_1919)	-	1979780..1980997 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
M013TW_RS09875 (M013TW_1920)	vraR	1981110..1981739 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
M013TW_RS09880 (M013TW_1921)	vraS	1981729..1982772 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
M013TW_RS09885 (M013TW_1922)	liaF	1982769..1983470 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
M013TW_RS09890 (M013TW_1923)	-	1983485..1983871 (-)	387	WP_001110179.1	hypothetical protein	-
M013TW_RS09895 (M013TW_1924)	map	1984088..1984846 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
M013TW_RS09900 (M013TW_1925)	-	1985375..1986361 (+)	987	WP_000999708.1	aromatic acid exporter family protein	-
M013TW_RS09910 (M013TW_1926)	-	1986794..1987207 (-)	414	WP_025174552.1	hypothetical protein	-
M013TW_RS09915 (M013TW_03620)	-	1987236..1987346 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=44058 M013TW_RS09880 WP_001017131.1 1981729..1982772(-) (vraS) [Staphylococcus aureus subsp. aureus M013]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=44058 M013TW_RS09880 WP_001017131.1 1981729..1982772(-) (vraS) [Staphylococcus aureus subsp. aureus M013]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1