NTDB

Overview

Name	sepM	Type	Regulator
Locus tag	HG420_RS02290	Genome accession	NZ_CP051518
Coordinates	436749..437780 (-)	Length	343 a.a.
NCBI ID	WP_011677213.1	Uniprot ID	A0A166ZHD8
Organism	Lactococcus cremoris strain F
Function	processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 431749..442780

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HG420_RS02260 (HG420_02265)	-	432952..433449 (-)	498	WP_011677211.1	nitroreductase family protein	-
HG420_RS02265 (HG420_02270)	-	433436..433645 (-)	210	WP_011677212.1	hypothetical protein	-
HG420_RS02275 (HG420_02280)	-	433933..434823 (+)	891	WP_015082946.1	IS982 family transposase	-
HG420_RS02280 (HG420_02285)	kwcM	434930..436249 (-)	1320	WP_015082947.1	KxxxW cyclic peptide radical SAM maturase	-
HG420_RS02285 (HG420_02290)	-	436317..436430 (-)	114	WP_011836076.1	KxxxW-cyclized peptide pheromone	-
HG420_RS02290 (HG420_02295)	sepM	436749..437780 (-)	1032	WP_011677213.1	SepM family pheromone-processing serine protease	Regulator
HG420_RS02295 (HG420_02300)	coaD	437764..438264 (-)	501	WP_011677214.1	pantetheine-phosphate adenylyltransferase	-
HG420_RS02300 (HG420_02305)	rsmD	438312..438851 (-)	540	WP_031286167.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
HG420_RS02305 (HG420_02310)	-	439021..440241 (-)	1221	WP_011677216.1	MFS transporter	-
HG420_RS02310 (HG420_02315)	lmrP	440321..441547 (-)	1227	Protein_448	multidrug efflux MFS transporter LmrP	-
HG420_RS02315 (HG420_02320)	-	441735..442229 (+)	495	WP_015082948.1	RNA polymerase sigma factor	-

Sequence

Protein

Download Length: 343 a.a. Molecular weight: 37398.03 Da Isoelectric Point: 9.8499

                                >NTDB_id=439459 HG420_RS02290 WP_011677213.1 436749..437780(-) (sepM) [Lactococcus cremoris strain F]

MKKKNKKISPKLKWGISIGLIIVALLVLVYPTNYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYS

HFNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAVYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELSDTITA

VNGEEFKSSADMIAYVSKQKVGDSVTIEYTRIDGSKHKSTGKYIKIANGKTGIGIGLVDHTEVVTDPKVTVNAGSIGGPS

AGIMFTLEIYSQLTGKDLRGGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAK

KLKTKMKIVPVKTIQDALDYLEK

Nucleotide

Download Length: 1032 bp

                                >NTDB_id=439459 HG420_RS02290 WP_011677213.1 436749..437780(-) (sepM) [Lactococcus cremoris strain F]

ATGAAGAAAAAAAATAAAAAAATCAGTCCCAAATTAAAATGGGGCATCTCTATTGGTCTGATTATTGTCGCTCTCCTTGT

TTTAGTGTATCCAACAAATTACTATGTGGAAATGCCTGGAACAACCGAGCCATTAGGAAAAATGGTCAAAGTCGAAGGAA

AAAAAGATGAGCACAAAGGTGACTTTTTCCTTACTACCGTTCAAATTGCGCGCGCTAATCTTGCCACAATGATTTACAGT

CATTTTAATAGTTTTACAAGCATTTACAGTGAACAAGAAATGACCGGTGGCCTTAATGATGCGCAGTTCAATCGTGTCAA

CCAGTTTTACATGGAAACGGCACAAAATACAGCCGTTTATCAGGCCTTCAAGTTGGCAAATAAACCCTATGAACTGAAAT

ATGAAGGGGTTTATGTCCTTGATATCGCTAAAAATTCGACTTTTAAAAATAAATTGGAACTTTCGGACACGATTACAGCA

GTCAATGGGGAAGAATTTAAATCAAGTGCAGATATGATTGCTTACGTTTCGAAGCAAAAAGTCGGCGATTCAGTTACCAT

TGAATATACACGGATTGATGGAAGTAAACACAAGTCTACTGGAAAATATATCAAAATCGCTAATGGAAAAACTGGAATCG

GAATTGGACTAGTTGACCATACTGAAGTAGTCACAGACCCAAAAGTTACAGTCAATGCAGGTTCAATCGGTGGACCATCT

GCCGGAATAATGTTTACACTAGAGATTTACAGTCAGTTGACAGGTAAAGATTTACGTGGTGGTCGCGAAATAGCAGGAAC

TGGAACGATTGAACATGATGGAAGCATTGGCCAAATCGGTGGGGTTGATAAAAAAGTAGCTACTGCTAGCAAAGAAGGCG

CAAAAGTTTTCTTAGTTCCTGACTCAGGCACCAAAAAAGAAAGCAGCAATAACTATCTTGGAGCCAAAGCAGCCGCTAAA

AAATTAAAAACGAAGATGAAAATTGTTCCCGTCAAGACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

Lon protease (S16) C-terminal proteolytic domain (Lon_C)

(229-339)

PDZ domain (PDZ_2)

(135-193)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A166ZHD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
sepM	Streptococcus mutans UA159	48.696	100	0.49

Detailed information NTG0439459