Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB10   Type   Machinery gene
Locus tag   HG573_RS05780 Genome accession   NZ_CP051494
Coordinates   1239544..1240743 (+) Length   399 a.a.
NCBI ID   WP_165540697.1    Uniprot ID   -
Organism   Helicobacter pylori strain PUNO-010     
Function   transformation-associated type IV transport system (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1224738..1282927 1239544..1240743 within 0


Gene organization within MGE regions


Location: 1224738..1282927
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HG573_RS05705 (HG573_05710) - 1225453..1226604 (-) 1152 WP_097679352.1 cation:proton antiporter -
  HG573_RS05710 (HG573_05715) - 1226630..1228009 (-) 1380 WP_202147091.1 HP1184 family multidrug efflux MATE transporter -
  HG573_RS05715 (HG573_05720) - 1228170..1229345 (-) 1176 WP_202147092.1 sugar transporter -
  HG573_RS05720 (HG573_05725) - 1229623..1230366 (+) 744 WP_001951723.1 carbonic anhydrase -
  HG573_RS05725 (HG573_05730) - 1230605..1231687 (-) 1083 WP_202147093.1 DUF874 family protein -
  HG573_RS05730 (HG573_05735) - 1231761..1232549 (+) 789 WP_202147094.1 integrase -
  HG573_RS05735 (HG573_05740) - 1232552..1232776 (+) 225 WP_021176077.1 hypothetical protein -
  HG573_RS05740 (HG573_05745) - 1232773..1233252 (+) 480 WP_202147095.1 hypothetical protein -
  HG573_RS05745 (HG573_05750) comB2 1233249..1233539 (+) 291 WP_202147096.1 TrbC/VirB2 family protein Machinery gene
  HG573_RS05750 (HG573_05755) comB3 1233549..1233812 (+) 264 WP_001177721.1 hypothetical protein Machinery gene
  HG573_RS05755 (HG573_05760) - 1233824..1234060 (+) 237 WP_202147097.1 hypothetical protein -
  HG573_RS05760 (HG573_05765) - 1234060..1236624 (+) 2565 Protein_1135 VirB4 family type IV secretion/conjugal transfer ATPase -
  HG573_RS05765 (HG573_05770) - 1236626..1236760 (+) 135 WP_202147098.1 type IV secretion system protein VirB7 -
  HG573_RS05770 (HG573_05775) - 1236753..1237919 (+) 1167 WP_202147099.1 VirB8/TrbF family protein -
  HG573_RS05775 (HG573_05780) - 1237916..1239547 (+) 1632 WP_202147100.1 TrbG/VirB9 family P-type conjugative transfer protein -
  HG573_RS05780 (HG573_05785) comB10 1239544..1240743 (+) 1200 WP_165540697.1 DNA type IV secretion system protein ComB10 Machinery gene
  HG573_RS05785 (HG573_05790) - 1240727..1242961 (+) 2235 WP_202147101.1 collagen-like protein -
  HG573_RS05790 (HG573_05795) - 1242974..1243945 (+) 972 WP_202147102.1 hypothetical protein -
  HG573_RS05795 (HG573_05800) - 1243963..1244235 (+) 273 WP_180373640.1 hypothetical protein -
  HG573_RS05800 (HG573_05805) - 1244240..1245184 (+) 945 WP_165530262.1 CpaF/VirB11 family protein -
  HG573_RS05805 (HG573_05810) - 1245181..1245699 (+) 519 WP_202147103.1 replication regulatory RepB family protein -
  HG573_RS05810 (HG573_05815) - 1245696..1247890 (+) 2195 Protein_1145 type IV secretory system conjugative DNA transfer family protein -
  HG573_RS05815 (HG573_05820) - 1247910..1256282 (+) 8373 WP_202147104.1 SNF2-related protein -
  HG573_RS05820 (HG573_05825) - 1256279..1258339 (+) 2061 WP_202147105.1 type IA DNA topoisomerase -
  HG573_RS05825 (HG573_05830) - 1258394..1258864 (+) 471 WP_000965794.1 hypothetical protein -
  HG573_RS05830 (HG573_05835) - 1258834..1259625 (+) 792 WP_202147106.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
  HG573_RS05835 (HG573_05840) - 1259751..1260422 (-) 672 WP_202147107.1 hypothetical protein -
  HG573_RS05840 (HG573_05845) - 1260400..1260792 (-) 393 WP_202147835.1 hypothetical protein -
  HG573_RS05845 (HG573_05850) - 1260833..1261501 (-) 669 WP_202147108.1 ParA family protein -
  HG573_RS05850 (HG573_05855) - 1262298..1262468 (+) 171 WP_202147109.1 hypothetical protein -
  HG573_RS05855 (HG573_05860) - 1262465..1263529 (+) 1065 WP_202147110.1 ArdC family protein -
  HG573_RS05860 (HG573_05865) - 1263529..1265289 (+) 1761 WP_202147111.1 hypothetical protein -
  HG573_RS05865 (HG573_05870) - 1265299..1266732 (+) 1434 WP_202147112.1 hypothetical protein -
  HG573_RS05870 (HG573_05875) - 1266732..1267988 (+) 1257 WP_202147113.1 type IV secretion system protein -
  HG573_RS05875 (HG573_05880) - 1268000..1269253 (+) 1254 WP_202147114.1 hypothetical protein -
  HG573_RS05880 (HG573_05885) - 1269257..1269907 (-) 651 WP_202147115.1 hypothetical protein -
  HG573_RS05885 (HG573_05890) ctkA 1270139..1271119 (+) 981 WP_001142075.1 serine/threonine-protein kinase CtkA -
  HG573_RS05890 (HG573_05895) - 1271289..1271972 (+) 684 WP_202147116.1 CAAX protease -
  HG573_RS05895 (HG573_05900) - 1272095..1272802 (+) 708 WP_202147117.1 Fic family protein -
  HG573_RS05900 (HG573_05905) - 1273184..1274251 (-) 1068 WP_202147118.1 tyrosine-type recombinase/integrase -
  HG573_RS05905 (HG573_05910) - 1275384..1277423 (-) 2040 WP_202147119.1 relaxase/mobilization nuclease domain-containing protein -
  HG573_RS05910 (HG573_05915) - 1278654..1279838 (-) 1185 WP_202147120.1 DUF874 family protein -
  HG573_RS05915 (HG573_05920) asd 1280271..1281311 (-) 1041 WP_202147121.1 aspartate-semialdehyde dehydrogenase -
  HG573_RS05920 (HG573_05925) hisS 1281298..1282626 (-) 1329 WP_202147122.1 histidine--tRNA ligase -

Sequence

Protein


Download         Length: 399 a.a.        Molecular weight: 44529.15 Da        Isoelectric Point: 9.9916

>NTDB_id=439058 HG573_RS05780 WP_165540697.1 1239544..1240743(+) (comB10) [Helicobacter pylori strain PUNO-010]
MNKSLLKKIGLVIGGFGVLMALGLLANKGSNNNNKEEIFQVSESKFPLSDYFFEEVKEEPKKEESPKTTTTPQPTAPTTA
NVSTNPIITDYSHLNNNLNKQHNTLTHLQQVLQSPPKIKPKPKHTKEQLEFLNTRLKPLEPTKPATKPETEYGVDSFTNL
KYKDIGTNEHKLLRTITADRMIPAFLITPISSQIAGKVTAQVESDIFASMGRAVLIPKGSKVIGYYNNDNQIGQYRLNIA
WTRIITPQGINIMLTNARGADVKGYNGLVGKYISRNFQRYGIPLLTNTLSNGLLIGITSALANNQNKKGDGNPFFGDYLL
MQLTRNTGMGINQVINQMLRQYGAQNPIIIIREGSRVFISPNLDIFIPKPKDGEVLAEFFKEKKPLITTKEEVNNEEEI

Nucleotide


Download         Length: 1200 bp        

>NTDB_id=439058 HG573_RS05780 WP_165540697.1 1239544..1240743(+) (comB10) [Helicobacter pylori strain PUNO-010]
ATGAATAAATCCTTGCTTAAAAAGATAGGCTTAGTTATAGGGGGCTTTGGCGTTTTAATGGCATTAGGACTGCTTGCTAA
TAAAGGCTCAAACAATAACAATAAAGAAGAAATCTTTCAAGTAAGCGAGAGTAAATTCCCCCTAAGTGATTATTTCTTTG
AAGAAGTCAAAGAAGAACCTAAAAAAGAAGAAAGCCCCAAAACAACAACCACGCCACAACCTACAGCTCCAACTACTGCT
AATGTTTCAACTAATCCTATCATTACAGATTATAGTCATCTTAACAACAATCTAAACAAGCAACATAACACCCTTACGCA
TTTACAACAAGTTTTACAAAGCCCCCCTAAAATAAAGCCTAAACCAAAACATACTAAAGAGCAATTAGAGTTTTTAAACA
CACGCCTTAAACCTTTAGAACCAACTAAACCAGCCACTAAGCCTGAGACGGAATATGGTGTGGATAGTTTTACTAATTTA
AAATATAAAGACATTGGCACTAATGAGCATAAGCTCTTAAGAACCATAACCGCTGATAGAATGATACCAGCCTTTTTGAT
CACGCCTATTAGCTCTCAAATTGCTGGAAAAGTAACCGCTCAAGTAGAGAGCGATATTTTTGCCTCTATGGGTAGAGCGG
TGCTAATCCCTAAAGGCTCTAAGGTTATAGGCTATTACAACAACGATAATCAAATCGGACAATACCGCTTAAACATTGCT
TGGACTAGAATTATCACCCCTCAAGGTATCAATATCATGCTCACTAATGCAAGAGGGGCTGATGTGAAAGGCTATAATGG
CTTAGTAGGCAAATACATTAGCCGAAATTTTCAACGCTATGGTATCCCCTTACTCACTAACACGCTTTCTAATGGGCTTT
TAATAGGAATTACTTCAGCCTTAGCTAATAACCAAAACAAAAAAGGTGATGGCAACCCTTTTTTTGGGGATTATTTGCTT
ATGCAACTCACTAGAAACACAGGCATGGGGATTAACCAAGTCATCAATCAAATGCTAAGACAATATGGAGCGCAAAACCC
CATTATCATCATTAGAGAGGGGAGCAGAGTGTTTATTAGCCCTAATTTAGACATTTTTATCCCTAAACCAAAAGATGGGG
AGGTTCTAGCGGAGTTTTTTAAAGAGAAAAAACCCCTAATCACAACAAAAGAGGAAGTTAACAATGAAGAAGAAATCTAA

Domains

Predicted by InterproScan.

Bacterial conjugation TrbI-like protein (TrbI)

(175-365)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB10 Helicobacter pylori P1

53.401

99.499

0.531