Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HG573_RS04035 Genome accession   NZ_CP051494
Coordinates   866104..867888 (+) Length   594 a.a.
NCBI ID   WP_202146889.1    Uniprot ID   -
Organism   Helicobacter pylori strain PUNO-010     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 861104..872888
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HG573_RS04000 - 861111..861461 (+) 351 Protein_802 osmoprotection protein -
  HG573_RS04005 (HG573_04005) - 861473..862045 (-) 573 WP_187920052.1 Hpy99I family type II restriction endonuclease -
  HG573_RS04010 (HG573_04010) - 862039..862857 (-) 819 WP_001944912.1 site-specific DNA-methyltransferase -
  HG573_RS04015 (HG573_04015) - 863247..864815 (+) 1569 WP_237392909.1 ABC transporter permease/substrate-binding protein -
  HG573_RS04020 (HG573_04020) - 864818..865459 (+) 642 WP_202146888.1 ATP-binding cassette domain-containing protein -
  HG573_RS04025 (HG573_04025) - 865471..865650 (-) 180 WP_000468794.1 hypothetical protein -
  HG573_RS04030 (HG573_04030) - 865642..866103 (+) 462 WP_000437184.1 hypothetical protein -
  HG573_RS04035 (HG573_04035) uvrC 866104..867888 (+) 1785 WP_202146889.1 excinuclease ABC subunit UvrC Machinery gene
  HG573_RS04040 (HG573_04040) - 867898..869163 (+) 1266 WP_156595992.1 homoserine dehydrogenase -
  HG573_RS04045 (HG573_04045) - 869164..869508 (+) 345 WP_001211718.1 YraN family protein -
  HG573_RS04050 (HG573_04050) trxA 869597..869917 (+) 321 WP_000020199.1 thioredoxin -
  HG573_RS04055 (HG573_04055) trxB 869923..870858 (+) 936 WP_120867411.1 thioredoxin-disulfide reductase -
  HG573_RS04060 (HG573_04060) - 871216..872037 (+) 822 WP_202146890.1 glycosyltransferase family 25 protein -
  HG573_RS04065 (HG573_04065) - 872241..872489 (-) 249 WP_000790556.1 RNA-binding protein -

Sequence

Protein


Download         Length: 594 a.a.        Molecular weight: 68751.14 Da        Isoelectric Point: 9.8177

>NTDB_id=439054 HG573_RS04035 WP_202146889.1 866104..867888(+) (uvrC) [Helicobacter pylori strain PUNO-010]
MADLLSSLKNLSHSSGVYQYFDKNHQLLYIGKAKNLKKRIKSYFSIRNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSSNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGKGHKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLN
ACSNETLKELQKFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDLILEEARSLFKLECMPYRVEIFDV
SHHANSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSNTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRK

Nucleotide


Download         Length: 1785 bp        

>NTDB_id=439054 HG573_RS04035 WP_202146889.1 866104..867888(+) (uvrC) [Helicobacter pylori strain PUNO-010]
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGCGTGTATCAATATTTTGACAAAAACCACCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCCATCCGCAATAATGAAATCACGCCCA
ATCATCGCGCAAGCTTACGAATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTAGAAAATTCTTTAATCAAGCAGCTCAAGCCTAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTAGACAGCTTGTATGAATTGCTCCCGTTGGTTCAAAAGAAA
AATTGCATCAAAGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGGATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAAAGACAGGCTCATCAAAGAGCTTGAATTGA
AAATGGAGCGCCTTTCTAGTAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGATAGGATTGCAAAAATCCAAAAAATC
GCCCCCTTCACTTGCATGGATTTAGCCAAACTCTACGATTTGGATATTTTTGCTTTTTATGGCAAGGGCCATAAGGCGGT
GTTGGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAACCATTACCAATCGCATTTGCCTTTGATGCCTGAGCAGATTTTATTGAAC
GCTTGCTCTAATGAAACGCTTAAAGAATTGCAAAAATTTATCTCCCACCAATACTCTAAAAAAATCGCTCTTAGTATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAGGAAAAAACCTCTA
ATGAAGATCTGATTTTAGAAGAAGCGCGATCGCTCTTTAAATTAGAGTGCATGCCTTATAGGGTGGAGATCTTTGATGTA
AGCCACCATGCCAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAATGCATTTCAAAAAAACTCTTATCGGCG
TTACCATTTAAAAGGCTCTAACGAATACGATCAAATGAGCGAATTGCTCACTAGAAGGGCTTTAGACTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATTGATGGAGGGAGGGCGCAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGTGCTAAAGACATTAT
CCATACGCCTAGCAATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAGTGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTGTTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCCGTTTTAAAAAAACGAAAATAA

Domains

Predicted by InterproScan.

UvrB/uvrC motif (UVR)

(205-239)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(385-538)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

97.302

99.832

0.971