Detailed information NTG0436766

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HF084_RS00465
• Genome accession: NZ_CP051191
• Coordinates: 84010..85053 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NGA102
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 79010..90053

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HF084_RS00435 (HF084_10220)	-	79436..79546 (+)	111	WP_001790257.1	hypothetical protein	-
HF084_RS00440 (HF084_10215)	-	79575..79988 (+)	414	WP_001670387.1	hypothetical protein	-
HF084_RS00445 (HF084_10210)	-	80419..81405 (-)	987	WP_000999716.1	aromatic acid exporter family protein	-
HF084_RS00450 (HF084_10205)	map	81936..82694 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HF084_RS00455 (HF084_10200)	-	82911..83297 (+)	387	WP_001110179.1	hypothetical protein	-
HF084_RS00460 (HF084_10195)	liaF	83312..84013 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HF084_RS00465 (HF084_10190)	vraS	84010..85053 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HF084_RS00470 (HF084_10185)	vraR	85043..85672 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
HF084_RS00475 (HF084_10180)	-	85788..87005 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
HF084_RS00480 (HF084_10175)	-	87283..87558 (-)	276	WP_000428171.1	hypothetical protein	-
HF084_RS00485 (HF084_10170)	-	87565..88029 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HF084_RS00490 (HF084_10165)	-	88176..88376 (+)	201	WP_000180460.1	DUF1128 family protein	-
HF084_RS00495 (HF084_10160)	-	88379..89635 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=436766 HF084_RS00465 WP_001017131.1 84010..85053(+) (vraS) [Staphylococcus aureus strain NGA102]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=436766 HF084_RS00465 WP_001017131.1 84010..85053(+) (vraS) [Staphylococcus aureus strain NGA102]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAGTTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1