Detailed information NTG0436469

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HF584_RS12745
• Genome accession: NZ_CP051165
• Coordinates: 2646773..2647816 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NGA84b
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2641773..2652816

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HF584_RS12715 (HF584_09875)	-	2641892..2642002 (+)	111	WP_001790257.1	hypothetical protein	-
HF584_RS12720 (HF584_09870)	-	2642031..2642444 (+)	414	WP_077446671.1	hypothetical protein	-
HF584_RS12725 (HF584_09865)	-	2642953..2643939 (-)	987	WP_054189634.1	aromatic acid exporter family protein	-
HF584_RS12730 (HF584_09860)	map	2644699..2645457 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HF584_RS12735 (HF584_09855)	-	2645674..2646060 (+)	387	WP_001110179.1	hypothetical protein	-
HF584_RS12740 (HF584_09850)	liaF	2646075..2646776 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HF584_RS12745 (HF584_09845)	vraS	2646773..2647816 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HF584_RS12750 (HF584_09840)	vraR	2647806..2648435 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
HF584_RS12755 (HF584_09835)	-	2648545..2649762 (-)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
HF584_RS12760 (HF584_09830)	-	2650040..2650315 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
HF584_RS12765 (HF584_09825)	-	2650322..2650786 (-)	465	WP_054189636.1	low molecular weight protein-tyrosine-phosphatase	-
HF584_RS12770 (HF584_09820)	-	2650933..2651133 (+)	201	WP_000180460.1	DUF1128 family protein	-
HF584_RS12775 (HF584_09815)	-	2651136..2652392 (+)	1257	WP_077446664.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=436469 HF584_RS12745 WP_001017131.1 2646773..2647816(+) (vraS) [Staphylococcus aureus strain NGA84b]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=436469 HF584_RS12745 WP_001017131.1 2646773..2647816(+) (vraS) [Staphylococcus aureus strain NGA84b]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTTATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACGGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACAAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTCCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCACTTGGTTTAAAAG
ACAAATCATTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1