Detailed information NTG0043522

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: SMUGS5_RS04305
• Genome accession: NC_018089
• Coordinates: 895201..897306 (-)
• Length: 701 a.a.
• NCBI ID: WP_002262823.1
• Uniprot ID: Q8DUH3
• Organism: Streptococcus mutans GS-5
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 890201..902306

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMUGS5_RS04285 (SMUGS5_04210)	mmuM	891322..892272 (+)	951	WP_002269978.1	homocysteine S-methyltransferase	-
SMUGS5_RS04290 (SMUGS5_04215)	-	892406..893668 (-)	1263	WP_002283146.1	PLP-dependent aminotransferase family protein	-
SMUGS5_RS04295 (SMUGS5_04220)	-	893766..894617 (+)	852	WP_014834951.1	pyridoxamine kinase	-
SMUGS5_RS04300 (SMUGS5_04225)	-	894614..895147 (+)	534	WP_002262822.1	ECF transporter S component	-
SMUGS5_RS04305 (SMUGS5_04230)	clpC	895201..897306 (-)	2106	WP_002262823.1	AAA family ATPase	Regulator
SMUGS5_RS04310 (SMUGS5_04235)	rplJ	897701..898204 (+)	504	WP_002262824.1	50S ribosomal protein L10	-
SMUGS5_RS04315 (SMUGS5_04240)	rplL	898270..898638 (+)	369	WP_002262825.1	50S ribosomal protein L7/L12	-
SMUGS5_RS04320 (SMUGS5_04245)	-	898905..899456 (+)	552	WP_002262826.1	carboxymuconolactone decarboxylase family protein	-
SMUGS5_RS04325 (SMUGS5_04250)	-	899477..900544 (+)	1068	WP_002262827.1	acyl-CoA dehydrogenase family protein	-
SMUGS5_RS04330 (SMUGS5_04255)	-	901136..902035 (-)	900	WP_002262828.1	polysaccharide deacetylase family protein	-

Sequence

Protein

• Length: 701 a.a.
• Molecular weight: 77185.93 Da
• Isoelectric Point: 4.7315

>NTDB_id=43522 SMUGS5_RS04305 WP_002262823.1 895201..897306(-) (clpC) [Streptococcus mutans GS-5]
MANFNGRDPFGNMDDIFNQLMGNMGGYNSENRRYLINGREVSPEEFAQYRQTGKLPGNPEIQQAQAAARTPKEDSILTKL
GNNLTEEARQGNLDPVIGRNKEIQETAEILARRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPASIKNKEVISIDISG
LEAGTQYRGAFEENIQNLVKEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADIIKPALSRGELTVIGATTQDEYRNT
IMKNAALARRFNEVKVNAPSAEDTYEILKGISALYEQHHNVILPKEVLKAAVDLSVQYIPQRSLPDKAIDLVDMTAAHLA
AQHPATDVKTLEKEIQTEKDKQQAAAEKEDYEEALKSKTKIDKLQAQIDNHTEGQKVTATINDVAEAVERLTGIPVSQMG
SSDIERLKEMNSRLKGKVIGQDEAVEAVSRAIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDMFGSKDSIIRL
DMSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIVLLDEIEKADSQVITLLLQVLDDGRLTDGQGNTINFKN
TVIIATSNAGFGNEALTGQEDKDMKIMDRIAPYFRPEFLNRFNAVIEFSHLSKEDLDEIVNLMLSEVNTTLAKKGIDLVV
SDSAKAHLIEEGYDEAMGVRPLRRVIEQEIRDKVTDFYLDHTDVKHLKAEMQDDKLIIEEA

Nucleotide

• Length: 2106 bp

>NTDB_id=43522 SMUGS5_RS04305 WP_002262823.1 895201..897306(-) (clpC) [Streptococcus mutans GS-5]
ATGGCAAATTTTAATGGACGCGATCCTTTTGGAAATATGGACGATATTTTTAATCAATTAATGGGTAATATGGGGGGATA
CAACTCTGAAAACCGTCGATATTTAATTAACGGTCGTGAAGTAAGTCCCGAAGAATTCGCACAATACAGACAAACAGGTA
AGCTTCCTGGCAATCCAGAAATACAGCAAGCTCAAGCTGCTGCTAGAACTCCAAAAGAAGACAGTATTTTGACTAAGCTT
GGTAACAATTTAACCGAAGAAGCCAGACAAGGTAACCTTGATCCTGTTATTGGACGGAATAAAGAAATTCAAGAAACTGC
TGAGATCTTAGCTCGGCGGACTAAAAACAATCCTGTTCTGGTCGGTGATGCCGGTGTTGGTAAAACAGCTGTCGTTGAAG
GCTTAGCACAGGCTATTGTTAACGGTGATGTCCCTGCCAGTATTAAAAATAAGGAAGTTATTTCTATTGATATTTCAGGA
TTAGAAGCTGGTACACAATACCGTGGTGCTTTCGAAGAAAATATTCAAAACTTGGTTAAAGAAGTCAAAGAAGCTGGCAA
TATCATCCTCTTCTTTGATGAAATTCATCAAATTTTAGGTGCTGGTTCAACTGGTGGTGACAGTGGTTCTAAAGGTTTGG
CAGACATTATCAAACCTGCTTTATCTCGCGGTGAATTGACTGTTATCGGTGCTACTACGCAAGATGAATACCGCAATACC
ATTATGAAAAACGCTGCATTGGCACGTCGTTTCAACGAAGTCAAAGTAAATGCACCTTCTGCTGAGGATACTTACGAAAT
TTTAAAAGGTATTTCAGCTCTCTACGAACAACATCATAATGTTATTTTGCCTAAGGAAGTTTTAAAAGCTGCTGTTGACT
TATCCGTACAATACATCCCGCAACGCAGTCTGCCTGATAAGGCCATTGACCTTGTTGATATGACAGCTGCTCATCTGGCT
GCTCAACATCCAGCAACTGATGTTAAGACACTTGAAAAAGAAATTCAAACTGAAAAAGATAAACAACAAGCTGCTGCTGA
AAAAGAAGATTATGAGGAAGCTCTTAAATCAAAAACTAAAATTGATAAACTGCAAGCACAAATTGACAATCATACTGAAG
GGCAAAAGGTTACTGCTACTATCAACGATGTGGCTGAGGCAGTTGAACGTTTGACAGGTATCCCTGTTTCGCAAATGGGA
AGCAGTGACATTGAACGTCTAAAAGAAATGAATTCTCGTCTCAAAGGCAAAGTTATTGGTCAAGATGAAGCTGTTGAAGC
TGTTTCACGCGCTATTCGCCGTAACCGTGCTGGTTTTGATGAAGGCAACCGTCCAATCGGCAGTTTCCTTTTTGTCGGAC
CTACTGGTGTTGGTAAAACAGAATTGGCTAAGCAGTTAGCCTTGGATATGTTTGGTTCTAAAGACTCTATTATCCGTCTT
GATATGTCAGAGTACAGTGATCGTACAGCTGTTTCCAAATTGATTGGTACTACTGCCGGTTATGTCGGCTATGATGATAA
CAGCAATACATTGACTGAACGTGTTCGCCGCAATCCTTATTCTATCGTTTTACTTGATGAGATTGAAAAGGCTGACTCTC
AAGTCATCACTCTTCTCCTTCAAGTATTGGATGATGGTCGTTTGACAGACGGACAAGGTAATACCATTAACTTTAAGAAT
ACCGTGATTATTGCAACTTCTAATGCTGGTTTTGGTAATGAAGCATTAACTGGTCAGGAAGATAAGGACATGAAGATCAT
GGATCGCATTGCCCCTTACTTCCGTCCCGAGTTTTTAAACCGTTTCAATGCAGTCATTGAATTCTCTCACTTAAGCAAAG
AAGACTTGGATGAAATCGTTAATCTCATGCTATCTGAAGTGAATACCACGCTTGCTAAGAAAGGAATTGATCTTGTTGTC
AGTGACAGCGCCAAGGCACATTTGATTGAAGAAGGTTATGACGAAGCAATGGGTGTTCGTCCATTACGCCGAGTTATCGA
GCAAGAAATTCGTGATAAAGTAACTGACTTCTATCTTGATCATACAGATGTTAAACATCTCAAAGCTGAAATGCAAGATG
ACAAATTGATTATTGAAGAAGCTTAA

Domains

Predicted by InterProScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (119-251)

• AAA domain (Cdc48 subfamily) (AAA_2) (444-604)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (611-682)

• AAA lid domain (AAA_lid_9) (260-356)

3D structure

• AlphaFold DB: Q8DUH3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. cremoris KW2	47.795	100	0.479
clpE	Streptococcus pneumoniae Rx1	46.901	100	0.475
clpE	Streptococcus pneumoniae D39	46.901	100	0.475
clpE	Streptococcus pneumoniae R6	46.901	100	0.475
clpE	Streptococcus pneumoniae TIGR4	46.942	100	0.471
clpE	Streptococcus mutans UA159	46.781	99.715	0.466
clpC	Bacillus subtilis subsp. subtilis str. 168	43.388	96.006	0.417
clpC	Streptococcus pneumoniae Rx1	44.098	87.019	0.384
clpC	Streptococcus pneumoniae D39	44.098	87.019	0.384
clpC	Streptococcus pneumoniae TIGR4	43.934	87.019	0.382
clpC	Streptococcus thermophilus LMD-9	42.673	88.588	0.378
clpC	Streptococcus mutans UA159	42.88	88.16	0.378
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.332	89.301	0.378
clpC	Streptococcus thermophilus LMG 18311	42.351	88.588	0.375