Detailed information NTG0434007

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HCU71_RS12045
• Genome accession: NZ_CP050691
• Coordinates: 2479671..2480714 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain PMB196-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2474671..2485714

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HCU71_RS12015 (HCU71_12015)	-	2475092..2476348 (-)	1257	WP_001795108.1	aminopeptidase	-
HCU71_RS12020 (HCU71_12020)	-	2476351..2476551 (-)	201	WP_000180460.1	DUF1128 family protein	-
HCU71_RS12025 (HCU71_12025)	-	2476698..2477162 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HCU71_RS12030 (HCU71_12030)	-	2477169..2477444 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
HCU71_RS12035 (HCU71_12035)	-	2477722..2478939 (+)	1218	WP_167780476.1	YihY/virulence factor BrkB family protein	-
HCU71_RS12040 (HCU71_12040)	vraR	2479052..2479681 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
HCU71_RS12045 (HCU71_12045)	vraS	2479671..2480714 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HCU71_RS12050 (HCU71_12050)	liaF	2480711..2481412 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HCU71_RS12055 (HCU71_12055)	-	2481427..2481813 (-)	387	WP_001110179.1	hypothetical protein	-
HCU71_RS12060 (HCU71_12060)	map	2482030..2482788 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HCU71_RS12065 (HCU71_12065)	-	2483260..2484246 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
HCU71_RS12070 (HCU71_12070)	-	2484677..2485090 (-)	414	WP_001557448.1	hypothetical protein	-
HCU71_RS12075 (HCU71_12075)	-	2485119..2485229 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=434007 HCU71_RS12045 WP_001017131.1 2479671..2480714(-) (vraS) [Staphylococcus aureus strain PMB196-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=434007 HCU71_RS12045 WP_001017131.1 2479671..2480714(-) (vraS) [Staphylococcus aureus strain PMB196-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1