Detailed information NTG0433948

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HCU70_RS09655
• Genome accession: NZ_CP050690
• Coordinates: 1971227..1972270 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain PMB179-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1966227..1977270

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HCU70_RS09625 (HCU70_09625)	-	1966594..1966704 (+)	111	WP_001790257.1	hypothetical protein	-
HCU70_RS09630 (HCU70_09630)	-	1966733..1967146 (+)	414	WP_001566709.1	hypothetical protein	-
HCU70_RS09635 (HCU70_09635)	-	1967636..1968622 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
HCU70_RS09640 (HCU70_09640)	map	1969153..1969911 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HCU70_RS09645 (HCU70_09645)	-	1970128..1970514 (+)	387	WP_001110179.1	hypothetical protein	-
HCU70_RS09650 (HCU70_09650)	liaF	1970529..1971230 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HCU70_RS09655 (HCU70_09655)	vraS	1971227..1972270 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HCU70_RS09660 (HCU70_09660)	vraR	1972260..1972889 (+)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
HCU70_RS09665 (HCU70_09665)	-	1973001..1974218 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
HCU70_RS09670 (HCU70_09670)	-	1974496..1974771 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
HCU70_RS09675 (HCU70_09675)	-	1974778..1975242 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HCU70_RS09680 (HCU70_09680)	-	1975389..1975589 (+)	201	WP_000180460.1	DUF1128 family protein	-
HCU70_RS09685 (HCU70_09685)	-	1975592..1976848 (+)	1257	WP_072419726.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=433948 HCU70_RS09655 WP_001017131.1 1971227..1972270(+) (vraS) [Staphylococcus aureus strain PMB179-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=433948 HCU70_RS09655 WP_001017131.1 1971227..1972270(+) (vraS) [Staphylococcus aureus strain PMB179-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGCATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1