Detailed information NTG0427894

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: G7052_RS08565
• Genome accession: NZ_CP049799
• Coordinates: 1761530..1762567 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 1040
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1756530..1767567

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G7052_RS08540 (G7052_08540)	-	1756534..1757061 (-)	528	WP_002983837.1	Dps family protein	-
G7052_RS08545 (G7052_08545)	-	1757289..1757915 (+)	627	WP_002983834.1	A24 family peptidase	-
G7052_RS08550 (G7052_08550)	rlmN	1757997..1759076 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
G7052_RS08555 (G7052_08555)	-	1759080..1759700 (-)	621	WP_002992791.1	YutD family protein	-
G7052_RS08560 (G7052_08560)	-	1760148..1761125 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
G7052_RS08565 (G7052_08565)	sepM	1761530..1762567 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
G7052_RS08570 (G7052_08570)	coaD	1762554..1763045 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
G7052_RS08575 (G7052_08575)	rsmD	1763035..1763574 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
G7052_RS08580 (G7052_08580)	asnA	1763697..1764689 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
G7052_RS08585 (G7052_08585)	arcC	1765002..1765952 (-)	951	WP_009880962.1	carbamate kinase	-
G7052_RS08590 (G7052_08590)	-	1765972..1767303 (-)	1332	WP_136273999.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=427894 G7052_RS08565 WP_010922499.1 1761530..1762567(-) (sepM) [Streptococcus pyogenes strain 1040]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=427894 G7052_RS08565 WP_010922499.1 1761530..1762567(-) (sepM) [Streptococcus pyogenes strain 1040]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693