Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   G8B37_RS00710 Genome accession   NZ_CP049695
Coordinates   109416..110369 (+) Length   317 a.a.
NCBI ID   WP_021299429.1    Uniprot ID   A0A660A6K5
Organism   Streptococcus pyogenes strain ABC76     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 104416..115369
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  G8B37_RS00670 (G8B37_00670) - 105243..105608 (+) 366 WP_002986560.1 DUF1033 family protein -
  G8B37_RS00675 (G8B37_00675) comYA 105701..106639 (+) 939 WP_002987773.1 competence type IV pilus ATPase ComGA Machinery gene
  G8B37_RS00680 (G8B37_00680) comYB 106575..107609 (+) 1035 WP_257577523.1 competence type IV pilus assembly protein ComGB Machinery gene
  G8B37_RS00685 (G8B37_00685) comYC 107611..107937 (+) 327 WP_011528161.1 competence type IV pilus major pilin ComGC Machinery gene
  G8B37_RS00690 (G8B37_00690) comGD 107912..108340 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  G8B37_RS00695 (G8B37_00695) comGE 108297..108581 (+) 285 WP_011528162.1 competence type IV pilus minor pilin ComGE -
  G8B37_RS00700 (G8B37_00700) comYF 108574..109008 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  G8B37_RS00705 (G8B37_00705) comGG 108992..109318 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  G8B37_RS00710 (G8B37_00710) comYH 109416..110369 (+) 954 WP_021299429.1 class I SAM-dependent methyltransferase Machinery gene
  G8B37_RS00715 (G8B37_00715) - 110428..111624 (+) 1197 WP_011528164.1 acetate kinase -
  G8B37_RS00720 (G8B37_00720) - 111811..112119 (+) 309 WP_011528165.1 hypothetical protein -
  G8B37_RS00725 (G8B37_00725) proC 112202..112972 (-) 771 WP_002986527.1 pyrroline-5-carboxylate reductase -
  G8B37_RS00730 (G8B37_00730) pepA 113020..114087 (-) 1068 WP_011528166.1 glutamyl aminopeptidase -
  G8B37_RS00735 (G8B37_00735) - 114552..114836 (+) 285 WP_002992749.1 DUF4651 domain-containing protein -
  G8B37_RS00740 (G8B37_00740) - 114833..115150 (+) 318 WP_011528167.1 thioredoxin family protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 36043.16 Da        Isoelectric Point: 4.7205

>NTDB_id=427124 G8B37_RS00710 WP_021299429.1 109416..110369(+) (comYH) [Streptococcus pyogenes strain ABC76]
MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEGASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQT
EQLQANHQFTPDAIGFILLYLLEQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSLKYLKKDGFAIFLVPVNLLTSPQ
SQLLKQWLKDYAQVVTLITLPDSIFGHPSNAKSIIVLQKQTDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN

Nucleotide


Download         Length: 954 bp        

>NTDB_id=427124 G8B37_RS00710 WP_021299429.1 109416..110369(+) (comYH) [Streptococcus pyogenes strain ABC76]
ATGACTTTTGAAAAAATTGAAGAAGCTTATCAGCTGCTCTTAGAGAACTGTCAACTAATTGAAAATGATCTAAAAACACA
TATATACGATGCCATTGTTGAACAAAACTCCTTTTATTTAGGGGCTGAGGGAGCTAGTCCTCAAGTTGCTCAAAATAGTG
ATAAACTGAAAGCCTTGTGCCTGACAAAAGAAGAATGGCGTAAGGCCTACCAGTTTCTTTTTATTAAGGCAGCTCAGACG
GAGCAACTCCAAGCCAACCATCAGTTCACACCAGATGCTATTGGCTTCATTCTGCTGTATCTTTTGGAACAATTGAGTGA
TAAAGATAGCTTAGAGGTACTTGAGATTGGAAGTGGAACAGGGAACCTAGCCCAAACCCTTCTCAACAACACGAGCAAGA
GCCTTGATTATGTAGGGATTGAACTTGATGATCTCTTGATTGATCTGTCAGCCAGTATTGCTGAGATAATGGATTCTTCA
GCTCATTTTATTCAAGAAGATGCGGTAAGGCCTCAATTACTAAAAGAAAGTGACATTGTCATCAGTGACTTACCAGTTGG
TTATTATCCTAACGATGATATTGCTAAACGGTACAAGGTGGCTAGTTCAGATAAGCATACCTATGCCCATCATTTATTAA
TGGAACAGTCTTTAAAATACCTGAAAAAAGACGGTTTTGCGATTTTTCTGGTACCAGTCAATTTATTGACAAGCCCTCAG
AGCCAGTTATTGAAACAGTGGTTAAAAGATTATGCTCAGGTGGTGACCTTGATTACGCTACCAGATTCTATTTTTGGTCA
TCCCTCAAATGCCAAGTCCATTATTGTCTTACAAAAACAAACAGACCACCCAATGGAAACCTTTGTCTATCCAATTCGGG
ATTTGAAGCTTGCAGAGAATATTCATGATTTTATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(68-288)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A660A6K5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA159

65.506

99.685

0.653
  comYH Streptococcus mutans UA140

65.19

99.685

0.65