Detailed information NTG0426651

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: G8B46_RS06100
• Genome accession: NZ_CP049686
• Coordinates: 1216006..1218288 (+)
• Length: 760 a.a.
• NCBI ID: WP_011528807.1
• Uniprot ID: A0A660A6J4
• Organism: Streptococcus pyogenes strain TSPY637
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 1211006..1223288

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B46_RS06080 (G8B46_06125)	-	1212375..1213784 (-)	1410	WP_002983891.1	deoxyribodipyrimidine photo-lyase	-
G8B46_RS06085 (G8B46_06130)	-	1213932..1214666 (-)	735	WP_002983889.1	amino acid ABC transporter ATP-binding protein	-
G8B46_RS06090 (G8B46_06135)	-	1214666..1215352 (-)	687	WP_002983887.1	amino acid ABC transporter permease	-
G8B46_RS06095 (G8B46_06140)	-	1215479..1215709 (-)	231	WP_002983885.1	YkuJ family protein	-
G8B46_RS06100 (G8B46_06145)	clpE	1216006..1218288 (+)	2283	WP_011528807.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
G8B46_RS06105 (G8B46_06150)	-	1218416..1218871 (+)	456	WP_219208671.1	NUDIX hydrolase	-
G8B46_RS06110 (G8B46_06155)	-	1218922..1219224 (+)	303	WP_002983878.1	DUF1827 family protein	-
G8B46_RS06115 (G8B46_06160)	ileS	1219489..1222290 (-)	2802	WP_011528809.1	isoleucine--tRNA ligase	-

Sequence

Protein

• Length: 760 a.a.
• Molecular weight: 84731.96 Da
• Isoelectric Point: 5.1035

>NTDB_id=426651 G8B46_RS06100 WP_011528807.1 1216006..1218288(+) (clpE) [Streptococcus pyogenes strain TSPY637]
MLCQNCNLNESTIHLYTSVNGKQRQVDLCQNCYQIMKSDPANSILNGLTPGYRAQDRSTSPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRYGGNYNGQRPAQPQTPNQQAKGLLEEFGINVTDIARNGNIDPVIGRDEEITRIIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKIIDGTVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
ITKYKEMQAQKVDEQDIPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLVNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSTNNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFS
PEFMNRFDGIIEFKALSKEHLLHIVDLMLEDVNERLGYNGIHLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKQLRALMTNSENITIKAVKEGDSFLNEKSLD

Nucleotide

• Length: 2283 bp

>NTDB_id=426651 G8B46_RS06100 WP_011528807.1 1216006..1218288(+) (clpE) [Streptococcus pyogenes strain TSPY637]
ATGCTGTGTCAAAATTGTAATTTAAACGAATCTACTATTCATCTTTATACAAGTGTTAATGGAAAACAAAGACAGGTTGA
TCTCTGTCAAAATTGTTATCAAATCATGAAATCCGATCCTGCCAATTCTATTTTAAATGGCCTAACCCCAGGATATAGAG
CACAAGATAGATCCACAAGTCCTTTCTTTGATGACTTTTTTGGTGATTTGAATAATTTTAGAGCTTTTGGTAATCTTCCA
AATACCCCACCTACTCAGGCAGGGCAAAATGGAAATGGCGGAGGACGCTATGGTGGTAACTACAACGGACAACGACCTGC
TCAGCCACAAACACCAAATCAGCAAGCAAAGGGCTTGTTAGAAGAGTTTGGGATTAATGTCACAGATATTGCAAGAAATG
GTAATATTGATCCTGTTATTGGTCGTGACGAAGAGATTACACGCATTATCGAGATCCTCAACCGCCGTACTAAAAATAAT
CCTGTGCTAATTGGTGAGCCTGGAGTTGGTAAAACTGCTGTTGTAGAAGGTTTGGCTCAAAAAATTATTGATGGTACTGT
TCCTCAAAAACTCCAAGGCAAGCAAGTGATTCGTCTTGATGTGGTTAGCCTCGTTCAGGGAACAGGTATCCGTGGTCAGT
TTGAAGAGCGCATGCAAAAATTAATGGAAGAAATTCGCAATCGCAAGGATGTGATTCTCTTTATTGATGAAATTCATGAG
ATTGTCGGTGCTGGTTCTGCAGGAGACGGCAATATGGATGCTGGTAATATTTTAAAACCAGCCTTGGCCCGCGGTGAATT
GCAGTTGGTCGGCGCTACCACCTTAAATGAATACCGTATTATTGAAAAAGACGCTGCCTTAGAACGACGTATGCAACCCG
TTAAAGTTGATGAACCTTCTGTTGAGGAAACCATCACGATTTTAAAAGGTATCCAACCGAAATACGAAGACTATCATCAT
GTCAAATATAGCCCAGCCGCTATTGAAGCTGCTGCTCATTTATCTAACCGCTATATTCAAGACCGTTTTCTTCCTGATAA
GGCTATTGACCTTCTGGACGAAGCTGGTTCCAAAATGAATCTAACCCTCAACTTTGTTGATCCTAAAGAAATTGACAAAC
GTCTTATTGAAGCTGAGAATCTCAAGGCGCAAGCTACTCGAGACGAAGACTATGAACGCGCAGCTTATTTCCGCGATCAA
ATTACAAAATACAAAGAAATGCAGGCTCAAAAAGTCGATGAGCAAGATATTCCCATCATTACTGAAAAAACCATTGAAGC
TATTGTAGAGCAAAAAACTAATATTCCAGTTGGGGACTTAAAAGAAAAGGAACAGTCTCAACTCGTAAACTTAGCCAATG
ATCTGAAAGCACACGTGATCGGGCAAGACGATGCTGTTGATAAAATCGCTAAGGCTATTCGTCGTAACCGTGTGGGATTA
GGAACTCCAAATCGCCCTATTGGTTCTTTCTTATTCGTTGGACCGACTGGGGTTGGTAAAACTGAATTGTCTAAACAACT
AGCCATTGAACTCTTTGGTTCGACAAACAATATGATTCGCTTTGACATGTCCGAATACATGGAAAAACACGCTGTCGCCA
AATTAGTCGGGGCTCCTCCAGGTTATGTCGGCTATGAAGAAGCTGGACAGCTAACCGAACAAGTTCGTCGCAATCCTTAT
TCCCTTATTCTCTTAGATGAGGTGGAAAAAGCCCATCCTGACGTCATGCACATGTTCTTACAAGTTCTTGATGACGGTCG
CTTAACAGACGGCCAAGGGCGAACAGTCAGCTTCAAGGACACCATTATTATCATGACCTCTAATGCCGGAACAGGTAAAA
GCGAAGCTTCTGTCGGATTTGGTGCTGCTAGAGAAGGACGGACAAGTTCTGTCCTTGGTGAATTAAGCAACTTCTTCAGC
CCAGAGTTTATGAATCGTTTCGATGGTATTATTGAATTCAAAGCTTTATCTAAAGAACATTTGCTGCATATCGTTGATTT
AATGCTGGAAGATGTTAATGAGCGCTTAGGCTATAATGGGATTCATCTTGATGTGACACAAAAGGTCAAAGAAAAATTAG
TAGATTTAGGCTATGATCCTAAAATGGGCGCTCGGCCGCTCCGTCGTACTATCCAAGATTATATCGAAGATGCCATTACA
GACTATTATTTAGAACACCCAACTGAAAAACAGTTACGTGCACTGATGACAAACAGTGAAAACATCACGATTAAAGCTGT
TAAAGAGGGAGATTCTTTTCTTAACGAAAAGTCTCTAGATTAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (300-397)

• ATPase family associated with various cellular activities (AAA) (AAA) (162-281)

• AAA domain (Cdc48 subfamily) (AAA_2) (485-648)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (656-729)

3D structure

• AlphaFold DB: A0A660A6J4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	84.626	98.421	0.833
clpE	Streptococcus pneumoniae Rx1	82.166	99.605	0.818
clpE	Streptococcus pneumoniae D39	82.166	99.605	0.818
clpE	Streptococcus pneumoniae R6	82.166	99.605	0.818
clpE	Streptococcus pneumoniae TIGR4	82.034	99.605	0.817
clpC	Lactococcus lactis subsp. cremoris KW2	76.965	97.105	0.747
clpC	Bacillus subtilis subsp. subtilis str. 168	51.442	86.711	0.446
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	46	85.526	0.393
clpC	Streptococcus pneumoniae Rx1	47.84	82.237	0.393
clpC	Streptococcus pneumoniae D39	47.84	82.237	0.393
clpC	Streptococcus pneumoniae TIGR4	47.84	82.237	0.393
clpC	Streptococcus mutans UA159	47.573	81.316	0.387
clpC	Streptococcus thermophilus LMD-9	47.115	82.105	0.387
clpC	Streptococcus thermophilus LMG 18311	46.795	82.105	0.384