Detailed information NTG0426645

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: G8B46_RS04715
• Genome accession: NZ_CP049686
• Coordinates: 932647..933483 (+)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain TSPY637
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 927647..938483

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B46_RS04685 (G8B46_04725)	-	928135..928569 (+)	435	WP_021299262.1	hypothetical protein	-
G8B46_RS04690 (G8B46_04730)	-	928619..929530 (-)	912	WP_011528643.1	diacylglycerol kinase family protein	-
G8B46_RS04695 (G8B46_04735)	-	929647..930297 (-)	651	WP_002984629.1	hemolysin III family protein	-
G8B46_RS04700 (G8B46_04740)	-	930294..930734 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
G8B46_RS04705 (G8B46_04745)	ylqF	930953..931801 (+)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
G8B46_RS04710 (G8B46_04750)	-	931791..932582 (+)	792	WP_011017771.1	ribonuclease HII	-
G8B46_RS04715 (G8B46_04755)	dprA	932647..933483 (+)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
G8B46_RS04720 (G8B46_04760)	topA	933590..935719 (+)	2130	WP_011528644.1	type I DNA topoisomerase	-
G8B46_RS04725 (G8B46_04765)	-	935795..936679 (-)	885	Protein_889	LysR family transcriptional regulator	-
G8B46_RS04730 (G8B46_04770)	-	936692..937258 (+)	567	Protein_890	PTS sugar transporter subunit IIC	-
G8B46_RS04735 (G8B46_04775)	-	937273..938265 (+)	993	WP_021299266.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=426645 G8B46_RS04715 WP_011017772.1 932647..933483(+) (dprA) [Streptococcus pyogenes strain TSPY637]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=426645 G8B46_RS04715 WP_011017772.1 932647..933483(+) (dprA) [Streptococcus pyogenes strain TSPY637]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367