Detailed information NTG0425297

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: G6Z52_RS05840
• Genome accession: NZ_CP049187
• Coordinates: 1196533..1197570 (-)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain TSPY1687
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1191533..1202570

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G6Z52_RS05815 (G6Z52_05850)	-	1191537..1192064 (-)	528	WP_002983837.1	Dps family protein	-
G6Z52_RS05820 (G6Z52_05855)	-	1192292..1192918 (+)	627	WP_002989076.1	A24 family peptidase	-
G6Z52_RS05825 (G6Z52_05860)	rlmN	1193000..1194079 (-)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
G6Z52_RS05830 (G6Z52_05865)	-	1194083..1194703 (-)	621	WP_032461520.1	YutD family protein	-
G6Z52_RS05835 (G6Z52_05870)	-	1195151..1196128 (-)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
G6Z52_RS05840 (G6Z52_05875)	sepM	1196533..1197570 (-)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
G6Z52_RS05845 (G6Z52_05880)	coaD	1197557..1198048 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
G6Z52_RS05850 (G6Z52_05885)	rsmD	1198038..1198577 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
G6Z52_RS05855 (G6Z52_05890)	asnA	1198700..1199692 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
G6Z52_RS05860 (G6Z52_05895)	arcC	1200006..1200956 (-)	951	WP_002989065.1	carbamate kinase	-
G6Z52_RS05865 (G6Z52_05900)	-	1200976..1202307 (-)	1332	WP_002989063.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=425297 G6Z52_RS05840 WP_002989068.1 1196533..1197570(-) (sepM) [Streptococcus pyogenes strain TSPY1687]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=425297 G6Z52_RS05840 WP_002989068.1 1196533..1197570(-) (sepM) [Streptococcus pyogenes strain TSPY1687]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69