Detailed information NTG0422531

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: G3G87_RS06160
• Genome accession: NZ_CP048714
• Coordinates: 1281247..1282290 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain CGMH-SL36
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1276247..1287290

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G3G87_RS06135	-	1276537..1277898 (-)	1362	WP_002477958.1	FAD-dependent oxidoreductase	-
G3G87_RS06140	-	1278032..1279012 (-)	981	WP_002477959.1	aromatic acid exporter family protein	-
G3G87_RS06145	map	1279257..1280012 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
G3G87_RS06150	-	1280138..1280524 (+)	387	WP_002477960.1	hypothetical protein	-
G3G87_RS06155	liaF	1280549..1281250 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
G3G87_RS06160	vraS	1281247..1282290 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
G3G87_RS06165	vraR	1282280..1282909 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
G3G87_RS06170	-	1283082..1284311 (-)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
G3G87_RS06175	-	1284514..1284798 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
G3G87_RS06180	-	1284805..1285269 (-)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
G3G87_RS06185	-	1285433..1285618 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
G3G87_RS06190	-	1285631..1286869 (+)	1239	WP_267477052.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=422531 G3G87_RS06160 WP_002461334.1 1281247..1282290(+) (vraS) [Staphylococcus lugdunensis strain CGMH-SL36]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=422531 G3G87_RS06160 WP_002461334.1 1281247..1282290(+) (vraS) [Staphylococcus lugdunensis strain CGMH-SL36]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCGCTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911