Detailed information NTG0422497

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: G3G86_RS05330
• Genome accession: NZ_CP048713
• Coordinates: 1140662..1141705 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain CGMH-SL138
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1135662..1146705

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G3G86_RS05305	-	1135952..1137313 (-)	1362	WP_037540479.1	FAD-dependent oxidoreductase	-
G3G86_RS05310	-	1137447..1138427 (-)	981	WP_002492696.1	aromatic acid exporter family protein	-
G3G86_RS05315	map	1138672..1139427 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
G3G86_RS05320	-	1139553..1139939 (+)	387	WP_002477960.1	hypothetical protein	-
G3G86_RS05325	liaF	1139964..1140665 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
G3G86_RS05330	vraS	1140662..1141705 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
G3G86_RS05335	vraR	1141695..1142324 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
G3G86_RS05340	-	1142497..1143726 (-)	1230	WP_002492699.1	YihY/virulence factor BrkB family protein	-
G3G86_RS05345	-	1143929..1144213 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
G3G86_RS05350	-	1144220..1144684 (-)	465	WP_002492719.1	low molecular weight protein-tyrosine-phosphatase	-
G3G86_RS05355	-	1144848..1145033 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
G3G86_RS05360	-	1145046..1146284 (+)	1239	WP_002461326.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=422497 G3G86_RS05330 WP_002461334.1 1140662..1141705(+) (vraS) [Staphylococcus lugdunensis strain CGMH-SL138]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=422497 G3G86_RS05330 WP_002461334.1 1140662..1141705(+) (vraS) [Staphylococcus lugdunensis strain CGMH-SL138]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911