Detailed information NTG0422005

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: GAU34_RS01485
• Genome accession: NZ_CP048643
• Coordinates: 318725..320074 (+)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain SR153
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	318725..340062	318725..320074	within	0

Gene organization within MGE regions

Location: 318725..340062

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GAU34_RS01485 (GAU34_01485)	ccrA	318725..320074 (+)	1350	WP_000815646.1	recombinase family protein	Machinery gene
GAU34_RS01490 (GAU34_01490)	ccrB	320096..321724 (+)	1629	WP_001186602.1	recombinase family protein	Machinery gene
GAU34_RS01495 (GAU34_01495)	-	322242..322592 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
GAU34_RS01500 (GAU34_01500)	-	322679..322990 (+)	312	WP_000700853.1	DUF960 family protein	-
GAU34_RS01505 (GAU34_01505)	-	323008..323514 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
GAU34_RS01510 (GAU34_01510)	-	323535..323852 (+)	318	WP_061641403.1	JAB domain-containing protein	-
GAU34_RS01515 (GAU34_01515)	-	323971..325056 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
GAU34_RS01520 (GAU34_01520)	-	325053..326945 (+)	1893	WP_001557544.1	site-specific integrase	-
GAU34_RS01525 (GAU34_01525)	-	326952..327329 (+)	378	WP_000361059.1	DUF6262 family protein	-
GAU34_RS01530 (GAU34_01530)	-	327480..328262 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
GAU34_RS01535 (GAU34_01535)	erm(A)	328388..329119 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
GAU34_RS01545 (GAU34_01545)	-	329628..330290 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
GAU34_RS01555 (GAU34_01555)	-	330635..331273 (-)	639	Protein_316	sulfite exporter TauE/SafE family protein	-
GAU34_RS01560 (GAU34_01560)	cstR	331273..331533 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
GAU34_RS01565 (GAU34_01565)	-	331669..332732 (+)	1064	Protein_318	DsrE/DsrF/DrsH-like family protein	-
GAU34_RS01570 (GAU34_01570)	cstB	332764..334098 (+)	1335	Protein_319	persulfide dioxygenase-sulfurtransferase CstB	-
GAU34_RS01580 (GAU34_01580)	-	334211..335320 (-)	1110	WP_000943131.1	ROK family transcriptional regulator	-
GAU34_RS01585 (GAU34_01585)	psm-mec	335675..335743 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
GAU34_RS01590 (GAU34_01590)	mecI	335828..336199 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
GAU34_RS01595 (GAU34_01595)	mecR1	336199..337956 (-)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
GAU34_RS01600 (GAU34_01600)	mecA	338053..340062 (+)	2010	WP_161081416.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=422005 GAU34_RS01485 WP_000815646.1 318725..320074(+) (ccrA) [Staphylococcus aureus strain SR153]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=422005 GAU34_RS01485 WP_000815646.1 318725..320074(+) (ccrA) [Staphylococcus aureus strain SR153]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748