Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   IB936_RS03625 Genome accession   NZ_CP061133
Coordinates   721895..723994 (-) Length   699 a.a.
NCBI ID   WP_011528518.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain BSAC_bs472 isolate Invasive disease     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 716895..728994
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IB936_RS03595 (IB936_03595) - 717372..718211 (+) 840 WP_011017679.1 thymidylate synthase -
  IB936_RS03600 (IB936_03600) - 718291..718788 (+) 498 WP_011528516.1 dihydrofolate reductase -
  IB936_RS03605 (IB936_03605) - 718808..718978 (+) 171 WP_002984950.1 hypothetical protein -
  IB936_RS03610 (IB936_03610) clpX 719108..720337 (+) 1230 WP_002984948.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  IB936_RS03615 (IB936_03615) yihA 720347..720946 (+) 600 WP_011184414.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  IB936_RS03620 (IB936_03620) - 721094..721837 (+) 744 WP_029713994.1 hypothetical protein -
  IB936_RS03625 (IB936_03625) clpC 721895..723994 (-) 2100 WP_011528518.1 AAA family ATPase Regulator
  IB936_RS03630 (IB936_03630) rpiA 724372..725055 (+) 684 WP_009881270.1 ribose-5-phosphate isomerase RpiA -
  IB936_RS03635 (IB936_03635) - 725132..726343 (+) 1212 WP_011528519.1 phosphopentomutase -
  IB936_RS03640 (IB936_03640) arsC 726362..726802 (+) 441 WP_002984932.1 arsenate reductase (glutaredoxin) -
  IB936_RS03645 (IB936_03645) - 726786..727595 (+) 810 WP_011528520.1 purine-nucleoside phosphorylase -
  IB936_RS03650 (IB936_03650) deoD 728258..728971 (+) 714 WP_011528521.1 purine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 699 a.a.        Molecular weight: 77420.56 Da        Isoelectric Point: 5.7992

>NTDB_id=420432 IB936_RS03625 WP_011528518.1 721895..723994(-) (clpC) [Streptococcus pyogenes strain BSAC_bs472 isolate Invasive disease]
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLG
TNLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKERQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQTQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSGFNIMDRIAPYFRPEFLNRFNSIIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLTIADDA
KAHLIDLGYNRAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ

Nucleotide


Download         Length: 2100 bp        

>NTDB_id=420432 IB936_RS03625 WP_011528518.1 721895..723994(-) (clpC) [Streptococcus pyogenes strain BSAC_bs472 isolate Invasive disease]
ATGACACATTTTTCTGGTAAAGATCCTTTTGTAAATATGGATGATATTTTCAACCAATTAATGGCAAACATGGGTGGTTA
TCGTAGCGAAAATCCCCGCTATCTCGTTAACGGTCGCGAAATAACTCCCGAAGAATTCCAACACTATCGTCAAACAGGAC
AACTCCCTGTAGCGACAACCAAAGCAACAAATTCTCAAATGTTAACACCTAAAGCTGATAGTGTATTGACTCAACTCGGA
ACTAACTTAACACAAGAAGCTCGTCAAGGGCATCTTGATCCCGTCATCGGTCGTAACAAAGAAATTCAAGATACCGCTGA
AATCTTGGCACGACGAACTAAAAATAATCCTGTCCTTGTCGGAGATGCTGGTGTCGGTAAAACTGCAGTCATTGAAGGTT
TAGCTCAAGCCATTGTTAATGGAGATGTCCCAGCTGCTATTAAAAACAAGGAAATCGTATCAATTGATATTTCTAGTCTT
GAAGCTGGTACACAGTATCGTGGTTCCTTTGAAGAGACCATTCAAAACTTGATTCAAGAAGTAAAAGAAGCTGGGAATAT
CATCTTATTTTTTGATGAAATTCATCAAATAGTTGGTGCTGGTGCCACAAGCAGTGATTCAGGCTCAAAGGGACTTGCAG
ATATTCTTAAACCAGCCTTGTCACGAGGAGAATTAACACTGATTGGTGCTACTACTCAAGACGAATACCGCAATACTATT
TTAAAAAATGCTGCTCTCGCTCGTCGCTTTAATGAAGTTAAAGTGAATGCACCATCAGCTGAAGATACTTTTCACATTTT
AATGGGTATTCGTAATCTTTATGAACAACACCACCATATTACCCTTCCTGATAATGTTCTAAAAGCTGCTGTTGATTATT
CTATTCAATACATCCCACAGCGTAGCCTGCCAGATAAAGCAATTGACTTACTGGATATGACAGCTGCTCATTTAGCTGCG
CAACACCCGGTCACTGACTTAAAAACACTCGAAACTGAAATAGCTAAACAAAAAGAGAGGCAAGAAAAAGCTGTCGCCAA
AGAAGACTTTGAAAAAGCTTTAGCAGCAAAAACACGGATTGAAACATTACAAAAGCAAATTGAGCAACATAACCAAACCC
AAAATGTCACTGCTACAGTCAATGATATCGCAGAGTCTGTAGAGCGCTTAACTGGTATTCCTGTCTCTAACATGGGGACT
AATGATTTAGAAAGGCTCAAAGGAATTAGCAGCCGCTTAAAAAGCCATGTCATCGGACAAGATGAGGCTGTTGCAGCAGT
AGCACGCGCTATTCGACGAAATCGAGCAGGTTTTGATGATGGTAACCGTCCAATAGGTTCTTTCCTTTTTGTGGGTCCAA
CTGGTGTTGGTAAAACAGAGTTAGCTAAACAATTAGCACTTGATTTATTTGGTTCCAAAGATGCTATTATTCGACTTGAT
ATGTCCGAATATAACGATCGCACTGCTGTGTCAAAATTGATTGGGACAACGGCTGGTTATGTTGGCTACGATGATAATAA
TAATACCCTAACTGAGCGTGTTCGTCGTAACCCTTATGCTATTGTCTTACTAGATGAAATTGAAAAAGCTGATCCTCAAA
TCATTACACTTCTTCTACAAGTGTTAGATGATGGACGATTGACAGATGGACAAGGAAATACTATTAACTTTAAAAATACC
GTTATTATTGCTACATCAAATGCCGGTTTTGGCCAACAAGATACGGAAACTTCTGGGTTTAACATTATGGATCGCATTGC
ACCTTATTTCAGACCAGAGTTTTTGAACCGTTTTAATAGTATCATTAAATTTAATCATCTGCAAAAAGAAAATTTAGAAG
AAATTGTTGATTTAATGCTAGCTGAAGTAAATCAAACCACCGCAAAAAAAGGTATTAGTTTAACGATTGCTGATGACGCT
AAAGCTCATTTGATAGATTTAGGGTACAATCGCGCTATGGGAGCTCGTCCATTACGACGTATTATCGAACAGGAAATTCG
TGACCGTATAACTGATTATTATCTTGACCATCCAGAAGTCAAAAAACTTCAGGCAATCCTAAAAGAAGGACAACTAGTGA
TTAGGCAAAACGATCAGTAA

Domains

Predicted by InterProScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(443-600)

ATPase family associated with various cellular activities (AAA) (AAA)

(118-250)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(607-678)

AAA lid domain (AAA_lid_9)

(259-353)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Lactococcus lactis subsp. cremoris KW2

47.159

100

0.475
  clpE Streptococcus mutans UA159

49.302

92.275

0.455
  clpE Streptococcus pneumoniae TIGR4

50.08

89.413

0.448
  clpE Streptococcus pneumoniae Rx1

50.08

89.413

0.448
  clpE Streptococcus pneumoniae D39

50.08

89.413

0.448
  clpE Streptococcus pneumoniae R6

50.08

89.413

0.448
  clpC Bacillus subtilis subsp. subtilis str. 168

44.511

95.136

0.423
  clpC Streptococcus thermophilus LMD-9

43.103

91.273

0.393
  clpC Streptococcus thermophilus LMG 18311

42.947

91.273

0.392
  clpC Streptococcus pneumoniae Rx1

41.871

93.276

0.391
  clpC Streptococcus pneumoniae D39

41.871

93.276

0.391
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

41.348

93.419

0.386
  clpC Streptococcus pneumoniae TIGR4

42.857

90.129

0.386
  clpC Streptococcus mutans UA159

41.406

91.559

0.379

Multiple sequence alignment