Detailed information NTG0418438

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: GWG03_RS00465
• Genome accession: NZ_CP047924
• Coordinates: 82743..83786 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SR130
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77743..88786

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GWG03_RS00435 (GWG03_00430)	-	78225..78335 (+)	111	WP_001790257.1	hypothetical protein	-
GWG03_RS00440 (GWG03_00435)	-	78364..78777 (+)	414	WP_001557448.1	hypothetical protein	-
GWG03_RS00445 (GWG03_00440)	-	79208..80194 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
GWG03_RS00450 (GWG03_00445)	map	80669..81427 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
GWG03_RS00455 (GWG03_00450)	-	81644..82030 (+)	387	WP_103147811.1	hypothetical protein	-
GWG03_RS00460 (GWG03_00455)	liaF	82045..82746 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
GWG03_RS00465 (GWG03_00460)	vraS	82743..83786 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
GWG03_RS00470 (GWG03_00465)	vraR	83776..84405 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
GWG03_RS00475 (GWG03_00470)	-	84518..85735 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
GWG03_RS00480 (GWG03_00475)	-	86013..86288 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
GWG03_RS00485 (GWG03_00480)	-	86295..86759 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
GWG03_RS00490 (GWG03_00485)	-	86906..87106 (+)	201	WP_000180460.1	DUF1128 family protein	-
GWG03_RS00495 (GWG03_00490)	-	87109..88365 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=418438 GWG03_RS00465 WP_001017131.1 82743..83786(+) (vraS) [Staphylococcus aureus strain SR130]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=418438 GWG03_RS00465 WP_001017131.1 82743..83786(+) (vraS) [Staphylococcus aureus strain SR130]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1