Detailed information NTG0418164

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: E3S59_RS09865
• Genome accession: NZ_CP047867
• Coordinates: 2006199..2007548 (+)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain UP_419
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2006199..2027564	2006199..2007548	within	0

Gene organization within MGE regions

Location: 2006199..2027564

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S59_RS09865 (E3S59_09865)	ccrA	2006199..2007548 (+)	1350	WP_000815646.1	cassette chromosome recombinase CcrA	Machinery gene
E3S59_RS09870 (E3S59_09870)	ccrB	2007570..2009198 (+)	1629	WP_001186602.1	cassette chromosome recombinase CcrB	Machinery gene
E3S59_RS09875 (E3S59_09875)	-	2009716..2010066 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
E3S59_RS09880 (E3S59_09880)	-	2010153..2010464 (+)	312	WP_000700853.1	DUF960 family protein	-
E3S59_RS09885 (E3S59_09885)	-	2010482..2010988 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
E3S59_RS09890 (E3S59_09890)	-	2011009..2011326 (+)	318	WP_000659050.1	JAB domain-containing protein	-
E3S59_RS09895 (E3S59_09895)	-	2011445..2012530 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
E3S59_RS09900 (E3S59_09900)	-	2012527..2014419 (+)	1893	WP_001557544.1	site-specific integrase	-
E3S59_RS09905 (E3S59_09905)	-	2014426..2014803 (+)	378	WP_000361059.1	DUF6262 family protein	-
E3S59_RS09910 (E3S59_09910)	-	2014954..2015736 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
E3S59_RS09915 (E3S59_09915)	erm(A)	2015862..2016593 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
E3S59_RS14255 (E3S59_09920)	-	2016676..2016735 (-)	60	WP_010959190.1	erythromycin resistance leader peptide	-
E3S59_RS09925 (E3S59_09925)	-	2017127..2017789 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
E3S59_RS09935 (E3S59_09935)	-	2018134..2018772 (-)	639	Protein_1922	sulfite exporter TauE/SafE family protein	-
E3S59_RS09940 (E3S59_09940)	cstR	2018772..2019032 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
E3S59_RS09945 (E3S59_09945)	-	2019168..2020232 (+)	1065	WP_160195533.1	DsrE/DsrF/DrsH-like family protein	-
E3S59_RS09950 (E3S59_09950)	cstB	2020265..2021599 (+)	1335	Protein_1925	persulfide dioxygenase-sulfurtransferase CstB	-
E3S59_RS09960 (E3S59_09960)	-	2021713..2022822 (-)	1110	WP_000943131.1	ROK family transcriptional regulator	-
E3S59_RS09965 (E3S59_09965)	psm-mec	2023177..2023245 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
E3S59_RS09970 (E3S59_09970)	mecI	2023330..2023701 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
E3S59_RS09975 (E3S59_09975)	mecR1	2023701..2025458 (-)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
E3S59_RS09980 (E3S59_09980)	mecA	2025555..2027564 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=418164 E3S59_RS09865 WP_000815646.1 2006199..2007548(+) (ccrA) [Staphylococcus aureus strain UP_419]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=418164 E3S59_RS09865 WP_000815646.1 2006199..2007548(+) (ccrA) [Staphylococcus aureus strain UP_419]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748