Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | E3S61_RS10230 | Genome accession | NZ_CP047865 |
| Coordinates | 2051290..2052639 (+) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain UP_844 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 2015787..2059510 | 2051290..2052639 | within | 0 |
| SCCmec | 2051290..2072655 | 2051290..2052639 | within | 0 |
Gene organization within MGE regions
Location: 2015787..2072655
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3S61_RS10075 (E3S61_10075) | - | 2015787..2018939 (-) | 3153 | WP_000080564.1 | DEAD/DEAH box helicase | - |
| E3S61_RS10080 (E3S61_10080) | - | 2019206..2019808 (-) | 603 | WP_000908956.1 | hypothetical protein | - |
| E3S61_RS10085 (E3S61_10085) | - | 2020016..2020312 (-) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| E3S61_RS10090 (E3S61_10090) | - | 2020361..2020564 (-) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| E3S61_RS10095 (E3S61_10095) | - | 2020873..2021859 (+) | 987 | WP_000662022.1 | tRNA dihydrouridine synthase | - |
| E3S61_RS10105 (E3S61_10105) | sqr | 2022525..2023718 (-) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| E3S61_RS10110 (E3S61_10110) | cstB | 2023737..2025071 (-) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| E3S61_RS10115 (E3S61_10115) | cstA | 2025102..2026166 (-) | 1065 | WP_000816133.1 | persulfide response sulfurtransferase CstA | - |
| E3S61_RS10120 (E3S61_10120) | cstR | 2026303..2026563 (+) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| E3S61_RS10125 (E3S61_10125) | - | 2026563..2027318 (+) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| E3S61_RS10130 (E3S61_10130) | - | 2027416..2027504 (+) | 89 | Protein_1962 | hypothetical protein | - |
| E3S61_RS10135 (E3S61_10135) | - | 2027809..2028164 (+) | 356 | Protein_1963 | tRNA-dihydrouridine synthase | - |
| E3S61_RS10140 (E3S61_10140) | - | 2028262..2030007 (-) | 1746 | WP_000700190.1 | DUF6119 family protein | - |
| E3S61_RS10145 (E3S61_10145) | - | 2030154..2030246 (-) | 93 | WP_001790000.1 | hypothetical protein | - |
| E3S61_RS10150 (E3S61_10150) | - | 2030210..2030344 (+) | 135 | WP_001790628.1 | hypothetical protein | - |
| E3S61_RS10155 (E3S61_10155) | - | 2030594..2032102 (-) | 1509 | WP_001001347.1 | protein kinase domain-containing protein | - |
| E3S61_RS10160 (E3S61_10160) | - | 2032217..2032843 (+) | 627 | WP_001176969.1 | hypothetical protein | - |
| E3S61_RS10165 (E3S61_10165) | - | 2033962..2034858 (+) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| E3S61_RS10170 (E3S61_10170) | - | 2034868..2035737 (+) | 870 | WP_000626133.1 | hypothetical protein | - |
| E3S61_RS10175 (E3S61_10175) | - | 2036282..2036838 (-) | 557 | Protein_1971 | K(+)-transporting ATPase subunit C | - |
| E3S61_RS10180 (E3S61_10180) | - | 2036854..2038875 (-) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| E3S61_RS10185 (E3S61_10185) | kdpA | 2038894..2040570 (-) | 1677 | WP_000029431.1 | potassium-transporting ATPase subunit KdpA | - |
| E3S61_RS14775 (E3S61_10190) | kdpF | 2040591..2040671 (-) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| E3S61_RS10195 (E3S61_10195) | - | 2040838..2043507 (+) | 2670 | WP_000446429.1 | sensor histidine kinase | - |
| E3S61_RS10200 (E3S61_10200) | - | 2043482..2044177 (+) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| E3S61_RS10205 (E3S61_10205) | - | 2044890..2045825 (+) | 936 | Protein_1977 | YfcC family protein | - |
| E3S61_RS14735 | - | 2046032..2046166 (-) | 135 | WP_001792216.1 | hypothetical protein | - |
| E3S61_RS10210 (E3S61_10210) | - | 2046336..2047477 (+) | 1142 | Protein_1979 | IS3-like element ISSau4 family transposase | - |
| E3S61_RS10215 (E3S61_10215) | - | 2047728..2048774 (+) | 1047 | WP_001060127.1 | hypothetical protein | - |
| E3S61_RS10220 (E3S61_10220) | ssb | 2048967..2049263 (+) | 297 | WP_000273824.1 | cassette chromosome ssDNA-binding protein | - |
| E3S61_RS10225 (E3S61_10225) | cch1 | 2049263..2051056 (+) | 1794 | WP_000195105.1 | cassette chromosome replicative helicase | - |
| E3S61_RS10230 (E3S61_10230) | ccrA | 2051290..2052639 (+) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| E3S61_RS10235 (E3S61_10235) | ccrB | 2052661..2054289 (+) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| E3S61_RS10240 (E3S61_10240) | - | 2054807..2055157 (+) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| E3S61_RS10245 (E3S61_10245) | - | 2055244..2055555 (+) | 312 | WP_000700853.1 | DUF960 family protein | - |
| E3S61_RS10250 (E3S61_10250) | - | 2055573..2056079 (+) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| E3S61_RS10255 (E3S61_10255) | - | 2056100..2056417 (+) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| E3S61_RS10260 (E3S61_10260) | - | 2056536..2057621 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| E3S61_RS10265 (E3S61_10265) | - | 2057618..2059510 (+) | 1893 | WP_001557544.1 | site-specific integrase | - |
| E3S61_RS10270 (E3S61_10270) | - | 2059517..2059894 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| E3S61_RS10275 (E3S61_10275) | - | 2060045..2060827 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| E3S61_RS10280 (E3S61_10280) | erm(A) | 2060953..2061684 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| E3S61_RS14795 (E3S61_10285) | - | 2061767..2061826 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| E3S61_RS10290 (E3S61_10290) | - | 2062218..2062880 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| E3S61_RS10300 (E3S61_10300) | - | 2063225..2063863 (-) | 639 | Protein_1996 | sulfite exporter TauE/SafE family protein | - |
| E3S61_RS10305 (E3S61_10305) | cstR | 2063863..2064123 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| E3S61_RS10310 (E3S61_10310) | - | 2064259..2065323 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| E3S61_RS10315 (E3S61_10315) | cstB | 2065356..2066690 (+) | 1335 | Protein_1999 | persulfide dioxygenase-sulfurtransferase CstB | - |
| E3S61_RS10325 (E3S61_10325) | - | 2066804..2067913 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| E3S61_RS10330 (E3S61_10330) | psm-mec | 2068268..2068336 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| E3S61_RS10335 (E3S61_10335) | mecI | 2068421..2068792 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| E3S61_RS10340 (E3S61_10340) | mecR1 | 2068792..2070549 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| E3S61_RS10345 (E3S61_10345) | mecA | 2070646..2072655 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=418121 E3S61_RS10230 WP_000815646.1 2051290..2052639(+) (ccrA) [Staphylococcus aureus strain UP_844]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=418121 E3S61_RS10230 WP_000815646.1 2051290..2052639(+) (ccrA) [Staphylococcus aureus strain UP_844]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |