Detailed information NTG0418077

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: E3S63_RS09895
• Genome accession: NZ_CP047863
• Coordinates: 2000494..2001843 (+)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain UP_1106
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2000494..2021858	2000494..2001843	within	0

Gene organization within MGE regions

Location: 2000494..2021858

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S63_RS09895 (E3S63_09895)	ccrA	2000494..2001843 (+)	1350	WP_000815646.1	cassette chromosome recombinase CcrA	Machinery gene
E3S63_RS09900 (E3S63_09900)	ccrB	2001865..2003493 (+)	1629	WP_001186602.1	cassette chromosome recombinase CcrB	Machinery gene
E3S63_RS09905 (E3S63_09905)	-	2004011..2004361 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
E3S63_RS09910 (E3S63_09910)	-	2004448..2004759 (+)	312	WP_000700853.1	DUF960 family protein	-
E3S63_RS09915 (E3S63_09915)	-	2004777..2005283 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
E3S63_RS09920 (E3S63_09920)	-	2005304..2005621 (+)	318	WP_000659050.1	JAB domain-containing protein	-
E3S63_RS09925 (E3S63_09925)	-	2005740..2006825 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
E3S63_RS09930 (E3S63_09930)	-	2006822..2008714 (+)	1893	WP_001557544.1	site-specific integrase	-
E3S63_RS09935 (E3S63_09935)	-	2008721..2009098 (+)	378	WP_000361059.1	DUF6262 family protein	-
E3S63_RS09940 (E3S63_09940)	-	2009249..2010031 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
E3S63_RS09945 (E3S63_09945)	erm(A)	2010157..2010888 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
E3S63_RS14425 (E3S63_09950)	-	2010971..2011030 (-)	60	WP_010959190.1	erythromycin resistance leader peptide	-
E3S63_RS09955 (E3S63_09955)	-	2011422..2012084 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
E3S63_RS09965 (E3S63_09965)	-	2012429..2013067 (-)	639	Protein_1929	sulfite exporter TauE/SafE family protein	-
E3S63_RS09970 (E3S63_09970)	cstR	2013067..2013327 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
E3S63_RS09975 (E3S63_09975)	-	2013463..2014527 (+)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
E3S63_RS09980 (E3S63_09980)	cstB	2014559..2015893 (+)	1335	Protein_1932	persulfide dioxygenase-sulfurtransferase CstB	-
E3S63_RS09990 (E3S63_09990)	-	2016007..2017116 (-)	1110	WP_000943131.1	ROK family transcriptional regulator	-
E3S63_RS09995 (E3S63_09995)	psm-mec	2017471..2017539 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
E3S63_RS10000 (E3S63_10000)	mecI	2017624..2017995 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
E3S63_RS10005 (E3S63_10005)	mecR1	2017995..2019752 (-)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
E3S63_RS10010 (E3S63_10010)	mecA	2019849..2021858 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=418077 E3S63_RS09895 WP_000815646.1 2000494..2001843(+) (ccrA) [Staphylococcus aureus strain UP_1106]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=418077 E3S63_RS09895 WP_000815646.1 2000494..2001843(+) (ccrA) [Staphylococcus aureus strain UP_1106]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748