Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   E3S64_RS10170 Genome accession   NZ_CP047861
Coordinates   2041513..2042862 (+) Length   449 a.a.
NCBI ID   WP_000815646.1    Uniprot ID   Q9XB96
Organism   Staphylococcus aureus strain UP_1322     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 2041513..2056166 2041513..2042862 within 0


Gene organization within MGE regions


Location: 2041513..2056166
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E3S64_RS10170 (E3S64_10170) ccrA 2041513..2042862 (+) 1350 WP_000815646.1 cassette chromosome recombinase CcrA Machinery gene
  E3S64_RS10175 (E3S64_10175) ccrB 2042884..2044512 (+) 1629 WP_001186602.1 cassette chromosome recombinase CcrB Machinery gene
  E3S64_RS10180 (E3S64_10180) - 2045030..2045380 (+) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  E3S64_RS10185 (E3S64_10185) - 2045467..2045778 (+) 312 WP_000700853.1 DUF960 family protein -
  E3S64_RS10190 (E3S64_10190) - 2045796..2046302 (+) 507 WP_001092169.1 DUF1643 domain-containing protein -
  E3S64_RS10195 (E3S64_10195) - 2046323..2046679 (+) 357 Protein_1979 JAB domain-containing protein -
  E3S64_RS10200 (E3S64_10200) - 2046736..2047374 (-) 639 Protein_1980 sulfite exporter TauE/SafE family protein -
  E3S64_RS10205 (E3S64_10205) cstR 2047374..2047634 (-) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  E3S64_RS10210 (E3S64_10210) - 2047770..2048834 (+) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  E3S64_RS10215 (E3S64_10215) cstB 2048867..2050201 (+) 1335 Protein_1983 persulfide dioxygenase-sulfurtransferase CstB -
  E3S64_RS10225 (E3S64_10225) - 2050315..2051424 (-) 1110 WP_000943131.1 ROK family transcriptional regulator -
  E3S64_RS10230 (E3S64_10230) psm-mec 2051779..2051847 (+) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  E3S64_RS10235 (E3S64_10235) mecI 2051932..2052303 (-) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  E3S64_RS10240 (E3S64_10240) mecR1 2052303..2054060 (-) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  E3S64_RS10245 (E3S64_10245) mecA 2054157..2056166 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52607.20 Da        Isoelectric Point: 9.9585

>NTDB_id=418033 E3S64_RS10170 WP_000815646.1 2041513..2042862(+) (ccrA) [Staphylococcus aureus strain UP_1322]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=418033 E3S64_RS10170 WP_000815646.1 2041513..2042862(+) (ccrA) [Staphylococcus aureus strain UP_1322]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9XB96

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

100

100

1
  ccrA Staphylococcus aureus COL

74.833

100

0.748

Multiple sequence alignment