Detailed information NTG0417821

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3S74_RS09865
• Genome accession: NZ_CP047851
• Coordinates: 2022377..2023420 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_338
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2017377..2028420

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S74_RS09835 (E3S74_09835)	-	2017798..2019054 (-)	1257	WP_001793983.1	aminopeptidase	-
E3S74_RS09840 (E3S74_09840)	-	2019057..2019257 (-)	201	WP_000180460.1	DUF1128 family protein	-
E3S74_RS09845 (E3S74_09845)	-	2019404..2019868 (+)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
E3S74_RS09850 (E3S74_09850)	-	2019875..2020150 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
E3S74_RS09855 (E3S74_09855)	-	2020428..2021645 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
E3S74_RS09860 (E3S74_09860)	vraR	2021758..2022387 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3S74_RS09865 (E3S74_09865)	vraS	2022377..2023420 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3S74_RS09870 (E3S74_09870)	liaF	2023417..2024118 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3S74_RS09875 (E3S74_09875)	-	2024133..2024519 (-)	387	WP_001110178.1	hypothetical protein	-
E3S74_RS09880 (E3S74_09880)	map	2024736..2025494 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3S74_RS09885 (E3S74_09885)	-	2026078..2027064 (+)	987	WP_001014423.1	FUSC family protein	-
E3S74_RS09890 (E3S74_09890)	-	2027253..2027666 (-)	414	WP_001643743.1	hypothetical protein	-
E3S74_RS09895 (E3S74_09895)	-	2027695..2027805 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=417821 E3S74_RS09865 WP_001017131.1 2022377..2023420(-) (vraS) [Staphylococcus aureus strain UP_338]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=417821 E3S74_RS09865 WP_001017131.1 2022377..2023420(-) (vraS) [Staphylococcus aureus strain UP_338]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1