Detailed information NTG0417745

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3S76_RS00490
• Genome accession: NZ_CP047849
• Coordinates: 91688..92731 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_403
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 86688..97731

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S76_RS00460 (E3S76_00460)	-	86999..87109 (+)	111	WP_001790257.1	hypothetical protein	-
E3S76_RS00465 (E3S76_00465)	-	87138..87551 (+)	414	WP_001549145.1	hypothetical protein	-
E3S76_RS00470 (E3S76_00470)	-	88041..89027 (-)	987	WP_000999713.1	FUSC family protein	-
E3S76_RS00475 (E3S76_00475)	map	89614..90372 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3S76_RS00480 (E3S76_00480)	-	90589..90975 (+)	387	WP_001110179.1	hypothetical protein	-
E3S76_RS00485 (E3S76_00485)	liaF	90990..91691 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3S76_RS00490 (E3S76_00490)	vraS	91688..92731 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3S76_RS00495 (E3S76_00495)	vraR	92721..93350 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
E3S76_RS00500 (E3S76_00500)	-	93466..94683 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
E3S76_RS00505 (E3S76_00505)	-	94961..95236 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
E3S76_RS00510 (E3S76_00510)	-	95243..95707 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E3S76_RS00515 (E3S76_00515)	-	95854..96054 (+)	201	WP_000180461.1	DUF1128 family protein	-
E3S76_RS00520 (E3S76_00520)	-	96057..97313 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=417745 E3S76_RS00490 WP_001017131.1 91688..92731(+) (vraS) [Staphylococcus aureus strain UP_403]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=417745 E3S76_RS00490 WP_001017131.1 91688..92731(+) (vraS) [Staphylococcus aureus strain UP_403]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1