Detailed information NTG0417577

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3S84_RS00490
• Genome accession: NZ_CP047841
• Coordinates: 90914..91957 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_644
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 85914..96957

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S84_RS00460 (E3S84_00460)	-	86401..86511 (+)	111	WP_001790257.1	hypothetical protein	-
E3S84_RS00465 (E3S84_00465)	-	86540..86953 (+)	414	WP_001670387.1	hypothetical protein	-
E3S84_RS00470 (E3S84_00470)	-	87384..88370 (-)	987	WP_047928543.1	FUSC family protein	-
E3S84_RS00475 (E3S84_00475)	map	88840..89598 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3S84_RS00480 (E3S84_00480)	-	89815..90201 (+)	387	WP_001110179.1	hypothetical protein	-
E3S84_RS00485 (E3S84_00485)	liaF	90216..90917 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3S84_RS00490 (E3S84_00490)	vraS	90914..91957 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3S84_RS00495 (E3S84_00495)	vraR	91947..92576 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3S84_RS00500 (E3S84_00500)	-	92688..93905 (-)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
E3S84_RS00505 (E3S84_00505)	-	94183..94458 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
E3S84_RS00510 (E3S84_00510)	-	94465..94929 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E3S84_RS00515 (E3S84_00515)	-	95076..95276 (+)	201	WP_000180460.1	DUF1128 family protein	-
E3S84_RS00520 (E3S84_00520)	-	95279..96535 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=417577 E3S84_RS00490 WP_001017131.1 90914..91957(+) (vraS) [Staphylococcus aureus strain UP_644]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=417577 E3S84_RS00490 WP_001017131.1 90914..91957(+) (vraS) [Staphylococcus aureus strain UP_644]
ATGAACCACTATATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1