Detailed information NTG0417403

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3S94_RS09470
• Genome accession: NZ_CP047830
• Coordinates: 1929061..1930104 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_996
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1924061..1935104

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S94_RS09440 (E3S94_09440)	-	1924479..1925735 (-)	1257	WP_001795438.1	aminopeptidase	-
E3S94_RS09445 (E3S94_09445)	-	1925738..1925938 (-)	201	WP_000180461.1	DUF1128 family protein	-
E3S94_RS09450 (E3S94_09450)	-	1926085..1926549 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E3S94_RS09455 (E3S94_09455)	-	1926556..1926831 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
E3S94_RS09460 (E3S94_09460)	-	1927109..1928326 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
E3S94_RS09465 (E3S94_09465)	vraR	1928442..1929071 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
E3S94_RS09470 (E3S94_09470)	vraS	1929061..1930104 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3S94_RS09475 (E3S94_09475)	liaF	1930101..1930802 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3S94_RS09480 (E3S94_09480)	-	1930817..1931203 (-)	387	WP_001110179.1	hypothetical protein	-
E3S94_RS09485 (E3S94_09485)	map	1931420..1932178 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3S94_RS09490 (E3S94_09490)	-	1932706..1933692 (+)	987	WP_000999713.1	FUSC family protein	-
E3S94_RS09495 (E3S94_09495)	-	1934182..1934595 (-)	414	WP_001549145.1	hypothetical protein	-
E3S94_RS09500 (E3S94_09500)	-	1934624..1934734 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=417403 E3S94_RS09470 WP_001017131.1 1929061..1930104(-) (vraS) [Staphylococcus aureus strain UP_996]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=417403 E3S94_RS09470 WP_001017131.1 1929061..1930104(-) (vraS) [Staphylococcus aureus strain UP_996]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1