Detailed information NTG0417285

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3T01_RS00455
• Genome accession: NZ_CP047826
• Coordinates: 82590..83633 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_1239
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77590..88633

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3T01_RS00425 (E3T01_00425)	-	77957..78067 (+)	111	WP_001790257.1	hypothetical protein	-
E3T01_RS00430 (E3T01_00430)	-	78096..78509 (+)	414	WP_001670387.1	hypothetical protein	-
E3T01_RS00435 (E3T01_00435)	-	78999..79985 (-)	987	WP_000999716.1	FUSC family protein	-
E3T01_RS00440 (E3T01_00440)	map	80516..81274 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3T01_RS00445 (E3T01_00445)	-	81491..81877 (+)	387	WP_001110179.1	hypothetical protein	-
E3T01_RS00450 (E3T01_00450)	liaF	81892..82593 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3T01_RS00455 (E3T01_00455)	vraS	82590..83633 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3T01_RS00460 (E3T01_00460)	vraR	83623..84252 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3T01_RS00465 (E3T01_00465)	-	84368..85585 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
E3T01_RS00470 (E3T01_00470)	-	85863..86138 (-)	276	WP_000428171.1	hypothetical protein	-
E3T01_RS00475 (E3T01_00475)	-	86145..86609 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E3T01_RS00480 (E3T01_00480)	-	86756..86956 (+)	201	WP_000180460.1	DUF1128 family protein	-
E3T01_RS00485 (E3T01_00485)	-	86959..88215 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=417285 E3T01_RS00455 WP_001017131.1 82590..83633(+) (vraS) [Staphylococcus aureus strain UP_1239]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=417285 E3T01_RS00455 WP_001017131.1 82590..83633(+) (vraS) [Staphylococcus aureus strain UP_1239]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAGTTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1