Detailed information NTG0417243

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3T02_RS00450
• Genome accession: NZ_CP047822
• Coordinates: 81941..82984 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_1278
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76941..87984

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3T02_RS00420 (E3T02_00420)	-	77367..77477 (+)	111	WP_001790257.1	hypothetical protein	-
E3T02_RS00425 (E3T02_00425)	-	77506..77919 (+)	414	WP_001566709.1	hypothetical protein	-
E3T02_RS00430 (E3T02_00430)	-	78350..79336 (-)	987	WP_000999713.1	FUSC family protein	-
E3T02_RS00435 (E3T02_00435)	map	79867..80625 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3T02_RS00440 (E3T02_00440)	-	80842..81228 (+)	387	WP_001110179.1	hypothetical protein	-
E3T02_RS00445 (E3T02_00445)	liaF	81243..81944 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3T02_RS00450 (E3T02_00450)	vraS	81941..82984 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3T02_RS00455 (E3T02_00455)	vraR	82974..83603 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3T02_RS00460 (E3T02_00460)	-	83715..84932 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
E3T02_RS00465 (E3T02_00465)	-	85210..85485 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
E3T02_RS00470 (E3T02_00470)	-	85492..85956 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E3T02_RS00475 (E3T02_00475)	-	86103..86303 (+)	201	WP_000180460.1	DUF1128 family protein	-
E3T02_RS00480 (E3T02_00480)	-	86306..87562 (+)	1257	WP_160194358.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=417243 E3T02_RS00450 WP_001017131.1 81941..82984(+) (vraS) [Staphylococcus aureus strain UP_1278]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=417243 E3T02_RS00450 WP_001017131.1 81941..82984(+) (vraS) [Staphylococcus aureus strain UP_1278]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACTCAAATATTTGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1