Detailed information NTG0417154

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3T08_RS09315
• Genome accession: NZ_CP047815
• Coordinates: 1919372..1920415 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_1484
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1914372..1925415

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3T08_RS09285 (E3T08_09285)	-	1914794..1916050 (-)	1257	WP_072419726.1	aminopeptidase	-
E3T08_RS09290 (E3T08_09290)	-	1916053..1916253 (-)	201	WP_000180460.1	DUF1128 family protein	-
E3T08_RS09295 (E3T08_09295)	-	1916400..1916864 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E3T08_RS09300 (E3T08_09300)	-	1916871..1917146 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
E3T08_RS09305 (E3T08_09305)	-	1917424..1918641 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
E3T08_RS09310 (E3T08_09310)	vraR	1918753..1919382 (-)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
E3T08_RS09315 (E3T08_09315)	vraS	1919372..1920415 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3T08_RS09320 (E3T08_09320)	liaF	1920412..1921113 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3T08_RS09325 (E3T08_09325)	-	1921128..1921514 (-)	387	WP_001110179.1	hypothetical protein	-
E3T08_RS09330 (E3T08_09330)	map	1921731..1922489 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3T08_RS09335 (E3T08_09335)	-	1923020..1924006 (+)	987	WP_000999713.1	FUSC family protein	-
E3T08_RS09340 (E3T08_09340)	-	1924437..1924850 (-)	414	WP_001566709.1	hypothetical protein	-
E3T08_RS09345 (E3T08_09345)	-	1924879..1924989 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=417154 E3T08_RS09315 WP_001017131.1 1919372..1920415(-) (vraS) [Staphylococcus aureus strain UP_1484]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=417154 E3T08_RS09315 WP_001017131.1 1919372..1920415(-) (vraS) [Staphylococcus aureus strain UP_1484]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGCATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1