Detailed information NTG0417019

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3T14_RS05550
• Genome accession: NZ_CP047809
• Coordinates: 1117229..1118272 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_1591
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1112229..1123272

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3T14_RS05520 (E3T14_05535)	-	1112647..1113903 (-)	1257	WP_001795438.1	aminopeptidase	-
E3T14_RS05525 (E3T14_05540)	-	1113906..1114106 (-)	201	WP_000180461.1	DUF1128 family protein	-
E3T14_RS05530 (E3T14_05545)	-	1114253..1114717 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E3T14_RS05535 (E3T14_05550)	-	1114724..1114999 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
E3T14_RS05540 (E3T14_05555)	-	1115277..1116494 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
E3T14_RS05545 (E3T14_05560)	vraR	1116610..1117239 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
E3T14_RS05550 (E3T14_05565)	vraS	1117229..1118272 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3T14_RS05555 (E3T14_05570)	liaF	1118269..1118970 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3T14_RS05560 (E3T14_05575)	-	1118985..1119371 (-)	387	WP_031896188.1	hypothetical protein	-
E3T14_RS05565 (E3T14_05580)	map	1119588..1120346 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3T14_RS05570 (E3T14_05585)	-	1120933..1121919 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
E3T14_RS05575 (E3T14_05590)	-	1122350..1122763 (-)	414	WP_161575775.1	hypothetical protein	-
E3T14_RS05580 (E3T14_05595)	-	1122792..1122902 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=417019 E3T14_RS05550 WP_001017131.1 1117229..1118272(-) (vraS) [Staphylococcus aureus strain UP_1591]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=417019 E3T14_RS05550 WP_001017131.1 1117229..1118272(-) (vraS) [Staphylococcus aureus strain UP_1591]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1