Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | E3S60_RS09850 | Genome accession | NZ_CP047804 |
| Coordinates | 2003343..2004692 (+) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain UP_774 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1967838..2011563 | 2003343..2004692 | within | 0 |
| SCCmec | 2003343..2024707 | 2003343..2004692 | within | 0 |
Gene organization within MGE regions
Location: 1967838..2024707
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3S60_RS09695 (E3S60_09695) | - | 1967838..1970990 (-) | 3153 | WP_000080564.1 | DEAD/DEAH box helicase | - |
| E3S60_RS09700 (E3S60_09700) | - | 1971257..1971859 (-) | 603 | WP_000908956.1 | hypothetical protein | - |
| E3S60_RS09705 (E3S60_09705) | - | 1972067..1972363 (-) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| E3S60_RS09710 (E3S60_09710) | - | 1972412..1972615 (-) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| E3S60_RS09715 (E3S60_09715) | - | 1972924..1973910 (+) | 987 | WP_000662022.1 | tRNA dihydrouridine synthase | - |
| E3S60_RS14220 | - | 1974096..1974310 (+) | 215 | Protein_1879 | universal stress protein | - |
| E3S60_RS09725 (E3S60_09725) | sqr | 1974577..1975770 (-) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| E3S60_RS09730 (E3S60_09730) | cstB | 1975789..1977123 (-) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| E3S60_RS09735 (E3S60_09735) | cstA | 1977154..1978218 (-) | 1065 | WP_000816133.1 | persulfide response sulfurtransferase CstA | - |
| E3S60_RS09740 (E3S60_09740) | cstR | 1978355..1978615 (+) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| E3S60_RS09745 (E3S60_09745) | - | 1978615..1979370 (+) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| E3S60_RS09750 (E3S60_09750) | - | 1979468..1979556 (+) | 89 | Protein_1885 | hypothetical protein | - |
| E3S60_RS09755 (E3S60_09755) | - | 1979861..1980216 (+) | 356 | Protein_1886 | tRNA-dihydrouridine synthase | - |
| E3S60_RS09760 (E3S60_09760) | - | 1980314..1982059 (-) | 1746 | WP_000700190.1 | DUF6119 family protein | - |
| E3S60_RS09765 (E3S60_09765) | - | 1982206..1982298 (-) | 93 | WP_001790000.1 | hypothetical protein | - |
| E3S60_RS09770 (E3S60_09770) | - | 1982262..1982396 (+) | 135 | WP_001790628.1 | hypothetical protein | - |
| E3S60_RS09775 (E3S60_09775) | - | 1982646..1984154 (-) | 1509 | WP_001001347.1 | protein kinase domain-containing protein | - |
| E3S60_RS09780 (E3S60_09780) | - | 1984269..1984895 (+) | 627 | WP_001176969.1 | hypothetical protein | - |
| E3S60_RS09785 (E3S60_09785) | - | 1986014..1986910 (+) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| E3S60_RS09790 (E3S60_09790) | - | 1986920..1987789 (+) | 870 | WP_000626133.1 | hypothetical protein | - |
| E3S60_RS09795 (E3S60_09795) | - | 1988334..1988891 (-) | 558 | WP_001193482.1 | K(+)-transporting ATPase subunit C | - |
| E3S60_RS09800 (E3S60_09800) | - | 1988907..1990928 (-) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| E3S60_RS09805 (E3S60_09805) | kdpA | 1990947..1992623 (-) | 1677 | WP_000029431.1 | potassium-transporting ATPase subunit KdpA | - |
| E3S60_RS14225 (E3S60_09810) | kdpF | 1992644..1992724 (-) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| E3S60_RS09815 (E3S60_09815) | - | 1992891..1995560 (+) | 2670 | WP_000446429.1 | sensor histidine kinase | - |
| E3S60_RS09820 (E3S60_09820) | - | 1995535..1996230 (+) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| E3S60_RS09825 (E3S60_09825) | - | 1996943..1997878 (+) | 936 | Protein_1900 | YfcC family protein | - |
| E3S60_RS09830 (E3S60_09830) | - | 1998389..1999530 (+) | 1142 | Protein_1901 | IS3-like element ISSau4 family transposase | - |
| E3S60_RS09835 (E3S60_09835) | - | 1999781..2000827 (+) | 1047 | WP_001060127.1 | hypothetical protein | - |
| E3S60_RS09840 (E3S60_09840) | ssb | 2001020..2001316 (+) | 297 | WP_000273824.1 | cassette chromosome ssDNA-binding protein | - |
| E3S60_RS09845 (E3S60_09845) | cch1 | 2001316..2003109 (+) | 1794 | WP_000195105.1 | cassette chromosome replicative helicase | - |
| E3S60_RS09850 (E3S60_09850) | ccrA | 2003343..2004692 (+) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| E3S60_RS09855 (E3S60_09855) | ccrB | 2004714..2006342 (+) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| E3S60_RS09860 (E3S60_09860) | - | 2006860..2007210 (+) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| E3S60_RS09865 (E3S60_09865) | - | 2007297..2007608 (+) | 312 | WP_000700853.1 | DUF960 family protein | - |
| E3S60_RS09870 (E3S60_09870) | - | 2007626..2008132 (+) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| E3S60_RS09875 (E3S60_09875) | - | 2008153..2008470 (+) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| E3S60_RS09880 (E3S60_09880) | - | 2008589..2009674 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| E3S60_RS09885 (E3S60_09885) | - | 2009671..2011563 (+) | 1893 | WP_001557544.1 | site-specific integrase | - |
| E3S60_RS09890 (E3S60_09890) | - | 2011570..2011947 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| E3S60_RS09895 (E3S60_09895) | - | 2012098..2012880 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| E3S60_RS09900 (E3S60_09900) | erm(A) | 2013006..2013737 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| E3S60_RS14250 (E3S60_09905) | - | 2013820..2013879 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| E3S60_RS09910 (E3S60_09910) | - | 2014271..2014933 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| E3S60_RS09920 (E3S60_09920) | - | 2015278..2015916 (-) | 639 | Protein_1918 | sulfite exporter TauE/SafE family protein | - |
| E3S60_RS09925 (E3S60_09925) | cstR | 2015916..2016176 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| E3S60_RS09930 (E3S60_09930) | - | 2016312..2017376 (+) | 1065 | WP_160195533.1 | DsrE/DsrF/DrsH-like family protein | - |
| E3S60_RS09935 (E3S60_09935) | cstB | 2017408..2018742 (+) | 1335 | Protein_1921 | persulfide dioxygenase-sulfurtransferase CstB | - |
| E3S60_RS09945 (E3S60_09945) | - | 2018856..2019965 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| E3S60_RS09950 (E3S60_09950) | psm-mec | 2020320..2020388 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| E3S60_RS09955 (E3S60_09955) | mecI | 2020473..2020844 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| E3S60_RS09960 (E3S60_09960) | mecR1 | 2020844..2022601 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| E3S60_RS09965 (E3S60_09965) | mecA | 2022698..2024707 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=416899 E3S60_RS09850 WP_000815646.1 2003343..2004692(+) (ccrA) [Staphylococcus aureus strain UP_774]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=416899 E3S60_RS09850 WP_000815646.1 2003343..2004692(+) (ccrA) [Staphylococcus aureus strain UP_774]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |