Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | E3S67_RS12890 | Genome accession | NZ_CP047802 |
| Coordinates | 2549574..2550923 (-) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain UP_1442 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 2542703..2586428 | 2549574..2550923 | within | 0 |
| SCCmec | 2529558..2550923 | 2549574..2550923 | within | 0 |
Gene organization within MGE regions
Location: 2529558..2586428
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3S67_RS12780 (E3S67_12780) | mecA | 2529558..2531567 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| E3S67_RS12785 (E3S67_12785) | mecR1 | 2531664..2533421 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| E3S67_RS12790 (E3S67_12790) | mecI | 2533421..2533792 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| E3S67_RS12795 (E3S67_12795) | psm-mec | 2533877..2533945 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| E3S67_RS12800 (E3S67_12800) | - | 2534279..2535409 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| E3S67_RS12805 (E3S67_12805) | cstB | 2535523..2536857 (-) | 1335 | Protein_2480 | persulfide dioxygenase-sulfurtransferase CstB | - |
| E3S67_RS12810 (E3S67_12810) | - | 2536890..2537954 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| E3S67_RS12815 (E3S67_12815) | cstR | 2538090..2538350 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| E3S67_RS12820 (E3S67_12820) | - | 2538350..2538988 (+) | 639 | Protein_2483 | sulfite exporter TauE/SafE family protein | - |
| E3S67_RS12830 (E3S67_12830) | - | 2539333..2539995 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| E3S67_RS14650 (E3S67_12835) | - | 2540387..2540446 (+) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| E3S67_RS12840 (E3S67_12840) | erm(A) | 2540529..2541260 (+) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| E3S67_RS12845 (E3S67_12845) | - | 2541386..2542168 (-) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| E3S67_RS12850 (E3S67_12850) | - | 2542319..2542696 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| E3S67_RS12855 (E3S67_12855) | - | 2542703..2544595 (-) | 1893 | WP_001557544.1 | site-specific integrase | - |
| E3S67_RS12860 (E3S67_12860) | - | 2544592..2545677 (-) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| E3S67_RS12865 (E3S67_12865) | - | 2545796..2546113 (-) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| E3S67_RS12870 (E3S67_12870) | - | 2546134..2546640 (-) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| E3S67_RS12875 (E3S67_12875) | - | 2546658..2546969 (-) | 312 | WP_000700853.1 | DUF960 family protein | - |
| E3S67_RS12880 (E3S67_12880) | - | 2547056..2547406 (-) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| E3S67_RS12885 (E3S67_12885) | ccrB | 2547924..2549552 (-) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| E3S67_RS12890 (E3S67_12890) | ccrA | 2549574..2550923 (-) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| E3S67_RS12895 (E3S67_12895) | cch1 | 2551157..2552950 (-) | 1794 | WP_000195105.1 | cassette chromosome replicative helicase | - |
| E3S67_RS12900 (E3S67_12900) | ssb | 2552950..2553246 (-) | 297 | WP_000273824.1 | cassette chromosome ssDNA-binding protein | - |
| E3S67_RS12905 (E3S67_12905) | - | 2553439..2554485 (-) | 1047 | WP_001060127.1 | hypothetical protein | - |
| E3S67_RS12910 (E3S67_12910) | - | 2554736..2555877 (-) | 1142 | Protein_2500 | IS3-like element ISSau4 family transposase | - |
| E3S67_RS12915 (E3S67_12915) | - | 2556388..2557323 (-) | 936 | Protein_2501 | YfcC family protein | - |
| E3S67_RS12920 (E3S67_12920) | - | 2558036..2558731 (-) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| E3S67_RS12925 (E3S67_12925) | - | 2558706..2561375 (-) | 2670 | WP_000446429.1 | sensor histidine kinase | - |
| E3S67_RS12930 (E3S67_12930) | kdpF | 2561542..2561622 (+) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| E3S67_RS12935 (E3S67_12935) | kdpA | 2561643..2563319 (+) | 1677 | WP_000029430.1 | potassium-transporting ATPase subunit KdpA | - |
| E3S67_RS12940 (E3S67_12940) | - | 2563338..2565359 (+) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| E3S67_RS12945 (E3S67_12945) | - | 2565375..2565932 (+) | 558 | WP_001193482.1 | K(+)-transporting ATPase subunit C | - |
| E3S67_RS12950 (E3S67_12950) | - | 2566477..2567346 (-) | 870 | WP_000626133.1 | hypothetical protein | - |
| E3S67_RS12955 (E3S67_12955) | - | 2567356..2568252 (-) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| E3S67_RS12960 (E3S67_12960) | - | 2569371..2569997 (-) | 627 | WP_001176969.1 | hypothetical protein | - |
| E3S67_RS12965 (E3S67_12965) | - | 2570112..2571620 (+) | 1509 | WP_001001347.1 | protein kinase domain-containing protein | - |
| E3S67_RS12970 (E3S67_12970) | - | 2571870..2572004 (-) | 135 | WP_001790628.1 | hypothetical protein | - |
| E3S67_RS12975 (E3S67_12975) | - | 2571968..2572060 (+) | 93 | WP_001790000.1 | hypothetical protein | - |
| E3S67_RS12980 (E3S67_12980) | - | 2572207..2573952 (+) | 1746 | WP_000700190.1 | DUF6119 family protein | - |
| E3S67_RS12985 (E3S67_12985) | - | 2574050..2574405 (-) | 356 | Protein_2515 | tRNA-dihydrouridine synthase | - |
| E3S67_RS12990 (E3S67_12990) | - | 2574710..2574798 (-) | 89 | Protein_2516 | hypothetical protein | - |
| E3S67_RS12995 (E3S67_12995) | - | 2574896..2575651 (-) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| E3S67_RS13000 (E3S67_13000) | cstR | 2575651..2575911 (-) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| E3S67_RS13005 (E3S67_13005) | cstA | 2576048..2577112 (+) | 1065 | WP_000816133.1 | persulfide response sulfurtransferase CstA | - |
| E3S67_RS13010 (E3S67_13010) | cstB | 2577143..2578477 (+) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| E3S67_RS13015 (E3S67_13015) | sqr | 2578496..2579689 (+) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| E3S67_RS14610 | - | 2579956..2580170 (-) | 215 | Protein_2522 | universal stress protein | - |
| E3S67_RS13025 (E3S67_13025) | - | 2580356..2581342 (-) | 987 | WP_000662022.1 | tRNA dihydrouridine synthase | - |
| E3S67_RS13030 (E3S67_13030) | - | 2581651..2581854 (+) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| E3S67_RS13035 (E3S67_13035) | - | 2581903..2582199 (+) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| E3S67_RS13040 (E3S67_13040) | - | 2582407..2583009 (+) | 603 | WP_000908956.1 | hypothetical protein | - |
| E3S67_RS13045 (E3S67_13045) | - | 2583276..2586428 (+) | 3153 | WP_000080564.1 | DEAD/DEAH box helicase | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=416820 E3S67_RS12890 WP_000815646.1 2549574..2550923(-) (ccrA) [Staphylococcus aureus strain UP_1442]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=416820 E3S67_RS12890 WP_000815646.1 2549574..2550923(-) (ccrA) [Staphylococcus aureus strain UP_1442]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |