Detailed information NTG0416735

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3S70_RS00455
• Genome accession: NZ_CP047801
• Coordinates: 84548..85591 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_248
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 79548..90591

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S70_RS00425 (E3S70_00425)	-	80048..80158 (+)	111	WP_001790257.1	hypothetical protein	-
E3S70_RS00430 (E3S70_00430)	-	80187..80600 (+)	414	WP_001643743.1	hypothetical protein	-
E3S70_RS00435 (E3S70_00435)	-	80789..81775 (-)	987	WP_001014423.1	FUSC family protein	-
E3S70_RS00440 (E3S70_00440)	map	82474..83232 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3S70_RS00445 (E3S70_00445)	-	83449..83835 (+)	387	WP_001110178.1	hypothetical protein	-
E3S70_RS00450 (E3S70_00450)	liaF	83850..84551 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3S70_RS00455 (E3S70_00455)	vraS	84548..85591 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3S70_RS00460 (E3S70_00460)	vraR	85581..86210 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3S70_RS00465 (E3S70_00465)	-	86323..87540 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
E3S70_RS00470 (E3S70_00470)	-	87818..88093 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
E3S70_RS00475 (E3S70_00475)	-	88100..88564 (-)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
E3S70_RS00480 (E3S70_00480)	-	88711..88911 (+)	201	WP_000180460.1	DUF1128 family protein	-
E3S70_RS00485 (E3S70_00485)	-	88914..90170 (+)	1257	WP_001793983.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=416735 E3S70_RS00455 WP_001017131.1 84548..85591(+) (vraS) [Staphylococcus aureus strain UP_248]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=416735 E3S70_RS00455 WP_001017131.1 84548..85591(+) (vraS) [Staphylococcus aureus strain UP_248]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1