Detailed information NTG0416693

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3S72_RS00500
• Genome accession: NZ_CP047800
• Coordinates: 91909..92952 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_296
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 86909..97952

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S72_RS00470 (E3S72_00470)	-	87394..87504 (+)	111	WP_001790257.1	hypothetical protein	-
E3S72_RS00475 (E3S72_00475)	-	87533..87946 (+)	414	WP_001557448.1	hypothetical protein	-
E3S72_RS00480 (E3S72_00480)	-	88377..89363 (-)	987	WP_000999717.1	FUSC family protein	-
E3S72_RS00485 (E3S72_00485)	map	89835..90593 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3S72_RS00490 (E3S72_00490)	-	90810..91196 (+)	387	WP_001110179.1	hypothetical protein	-
E3S72_RS00495 (E3S72_00495)	liaF	91211..91912 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3S72_RS00500 (E3S72_00500)	vraS	91909..92952 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3S72_RS00505 (E3S72_00505)	vraR	92942..93571 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3S72_RS00510 (E3S72_00510)	-	93684..94901 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
E3S72_RS00515 (E3S72_00515)	-	95179..95454 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
E3S72_RS00520 (E3S72_00520)	-	95461..95925 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E3S72_RS00525 (E3S72_00525)	-	96072..96272 (+)	201	WP_000180460.1	DUF1128 family protein	-
E3S72_RS00530 (E3S72_00530)	-	96275..97531 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=416693 E3S72_RS00500 WP_001017131.1 91909..92952(+) (vraS) [Staphylococcus aureus strain UP_296]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=416693 E3S72_RS00500 WP_001017131.1 91909..92952(+) (vraS) [Staphylococcus aureus strain UP_296]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1