Detailed information NTG0416653

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3S73_RS00445
• Genome accession: NZ_CP047799
• Coordinates: 81567..82610 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_322
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76567..87610

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S73_RS00415 (E3S73_00415)	-	77010..77120 (+)	111	WP_001790257.1	hypothetical protein	-
E3S73_RS00420 (E3S73_00420)	-	77149..77562 (+)	414	WP_001643743.1	hypothetical protein	-
E3S73_RS00425 (E3S73_00425)	-	77751..78737 (-)	987	WP_001014423.1	FUSC family protein	-
E3S73_RS00430 (E3S73_00430)	map	79493..80251 (+)	759	WP_123090064.1	type I methionyl aminopeptidase	-
E3S73_RS00435 (E3S73_00435)	-	80468..80854 (+)	387	WP_001110178.1	hypothetical protein	-
E3S73_RS00440 (E3S73_00440)	liaF	80869..81570 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3S73_RS00445 (E3S73_00445)	vraS	81567..82610 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3S73_RS00450 (E3S73_00450)	vraR	82600..83229 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3S73_RS00455 (E3S73_00455)	-	83342..84559 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
E3S73_RS00460 (E3S73_00460)	-	84837..85112 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
E3S73_RS00465 (E3S73_00465)	-	85119..85583 (-)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
E3S73_RS00470 (E3S73_00470)	-	85730..85930 (+)	201	WP_000180460.1	DUF1128 family protein	-
E3S73_RS00475 (E3S73_00475)	-	85933..87189 (+)	1257	WP_001793983.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=416653 E3S73_RS00445 WP_001017131.1 81567..82610(+) (vraS) [Staphylococcus aureus strain UP_322]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=416653 E3S73_RS00445 WP_001017131.1 81567..82610(+) (vraS) [Staphylococcus aureus strain UP_322]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1