Detailed information NTG0416551

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3S78_RS11345
• Genome accession: NZ_CP047796
• Coordinates: 2364100..2365143 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_462
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2359100..2370143

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S78_RS11315 (E3S78_11315)	-	2359599..2359709 (+)	111	WP_001790257.1	hypothetical protein	-
E3S78_RS11320 (E3S78_11320)	-	2359738..2360151 (+)	414	WP_001643743.1	hypothetical protein	-
E3S78_RS11325 (E3S78_11325)	-	2360340..2361326 (-)	987	WP_001014423.1	FUSC family protein	-
E3S78_RS11330 (E3S78_11330)	map	2362026..2362784 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3S78_RS11335 (E3S78_11335)	-	2363001..2363387 (+)	387	WP_001110178.1	hypothetical protein	-
E3S78_RS11340 (E3S78_11340)	liaF	2363402..2364103 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
E3S78_RS11345 (E3S78_11345)	vraS	2364100..2365143 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3S78_RS11350 (E3S78_11350)	vraR	2365133..2365762 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
E3S78_RS11355 (E3S78_11355)	-	2365875..2367092 (-)	1218	WP_160176212.1	YihY/virulence factor BrkB family protein	-
E3S78_RS11360 (E3S78_11360)	-	2367370..2367645 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
E3S78_RS11365 (E3S78_11365)	-	2367652..2368116 (-)	465	WP_160176213.1	low molecular weight protein-tyrosine-phosphatase	-
E3S78_RS11370 (E3S78_11370)	-	2368263..2368463 (+)	201	WP_000180460.1	DUF1128 family protein	-
E3S78_RS11375 (E3S78_11375)	-	2368466..2369722 (+)	1257	WP_001793983.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=416551 E3S78_RS11345 WP_001017131.1 2364100..2365143(+) (vraS) [Staphylococcus aureus strain UP_462]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=416551 E3S78_RS11345 WP_001017131.1 2364100..2365143(+) (vraS) [Staphylococcus aureus strain UP_462]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1