Detailed information NTG0416446

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3S81_RS00455
• Genome accession: NZ_CP047794
• Coordinates: 82455..83498 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_551
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77455..88498

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S81_RS00425 (E3S81_00425)	-	78016..78126 (+)	111	WP_001790257.1	hypothetical protein	-
E3S81_RS00430 (E3S81_00430)	-	78155..78568 (+)	414	WP_025174475.1	hypothetical protein	-
E3S81_RS00435 (E3S81_00435)	-	78757..79743 (-)	987	WP_000999713.1	FUSC family protein	-
E3S81_RS00440 (E3S81_00440)	map	80381..81139 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3S81_RS00445 (E3S81_00445)	-	81356..81742 (+)	387	WP_001110179.1	hypothetical protein	-
E3S81_RS00450 (E3S81_00450)	liaF	81757..82458 (+)	702	WP_106459782.1	cell wall-active antibiotics response protein LiaF	-
E3S81_RS00455 (E3S81_00455)	vraS	82455..83498 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3S81_RS00460 (E3S81_00460)	vraR	83488..84117 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
E3S81_RS00465 (E3S81_00465)	-	84230..85447 (-)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
E3S81_RS00470 (E3S81_00470)	-	85725..86000 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
E3S81_RS00475 (E3S81_00475)	-	86007..86471 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E3S81_RS00480 (E3S81_00480)	-	86618..86818 (+)	201	WP_000180462.1	DUF1128 family protein	-
E3S81_RS00485 (E3S81_00485)	-	86821..88077 (+)	1257	WP_078103411.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=416446 E3S81_RS00455 WP_001017131.1 82455..83498(+) (vraS) [Staphylococcus aureus strain UP_551]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=416446 E3S81_RS00455 WP_001017131.1 82455..83498(+) (vraS) [Staphylococcus aureus strain UP_551]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1